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Dylan Field, CEO of Figma, discusses the platform's journey from a design tool to a collaborative ecosystem, sharing insights on innovation, leadership, and the transformative potential of AI in creative processes.
In this quarterly Bitcoin Mastermind podcast, experts analyze geopolitical tensions, the potential impact of AI on economic models, cryptocurrency regulations, and Bitcoin's market dynamics while exploring global power shifts and technological disruption.
Jason interviews Alex Shieh of The Antifraud Company, who uses AI and investigative techniques to uncover government fraud and collect bounties under the False Claims Act, with the potential to expose billions in fraudulent spending.
Tony Robbins discusses the impending AI disruption, emphasizing the need for individuals to develop an identity as a creator, master pattern recognition, and find purpose beyond traditional work in order to navigate the massive technological and economic changes ahead.
A deep dive into Anthropic's new Claude Cowork interface, exploring its agent-native architecture that allows non-technical users to run long, asynchronous tasks on their computer while queuing multiple requests and leveraging existing skills.
A podcast team creates their own social media platform in the Fediverse to explore whether they can build a better, more human-centric online community that doesn't rely on engagement-driven algorithms.
Ben Horowitz discusses how AI is transforming venture capital by accelerating decision-making, forcing firms to evaluate investors at the point of investment, and creating opportunities across multiple verticals while reflecting unprecedented market demand.
The unlikely journey of Ladder, a fitness app that went from near-death to becoming the #1 grossing fitness app, driven by relentless customer understanding, innovative TikTok growth, and a laser-focused approach to solving user problems.
Scott Hanselman and Ryan Donovan discuss the nuances of "vibe coding" with AI, exploring how human judgment, experience, and context remain crucial in software development, even as AI tools become more sophisticated.
Jason interviews Sho Takei, co-founder of HyreSearch, about startup recruiting in Japan and the US, discussing AI's impact on hiring, talent acquisition strategies, and cultural differences in the recruitment process.
In this episode, M.G. Siegler and Alex discuss the current state of AI, exploring whether the technology needs a Steve Jobs-like figure, analyzing the AI chaos among big tech companies, and making predictions about the tech landscape in 2026.
A deep dive into venture capital with Alex Rampell, exploring investment strategies, the changing startup landscape, AI's impact on labor and technology, and the critical importance of finding high-agency founders who can materialize labor, capital, and customers.
Tarun Thummala founded PressW, an AI engineering firm that builds custom automation systems for regulated industries, generating over $2 million annually by focusing on specific workflow outcomes and leveraging AI to streamline their own business processes.
A Stanford-trained scientist explores the cutting-edge world of magnetogenetics, developing a new technology at Nonfiction Labs that could revolutionize cancer therapies by using magnets to precisely control drug targeting in the body.
Dr. Michael Power argues that Chinese AI, with its open-source approach and cost advantages, is poised to outmaneuver and potentially dominate the U.S. AI industry in the coming years.
Gary Vaynerchuk discusses the evolving landscape of digital marketing, emphasizing the importance of organic social content, measuring creative success, and leveraging platforms like Google Shorts and TikTok to feed AI language models while driving business growth.
Glean CEO Arvind Jain discusses the rapidly evolving AI landscape, emphasizing that businesses are only utilizing 1% of current AI capabilities and that the key to success lies in continuous innovation and adaptability.
At CES 2026, Havas CEO Yannick Bolloré discusses how AI can help scale intelligence and creativity while maintaining the human connection, demonstrating this through a live experiment where his team creates a movie trailer for volunteer Amanda using AI-powered production tools.
Luke Harries, Head of Growth at ElevenLabs, shares insights on their unique growth strategy, product expansion, launching techniques, and how they've built a $6.6B growth engine without traditional product managers.
In this episode, Aishwarya Naresh Reganti and Kiriti Badam share insights on building successful AI products, emphasizing the importance of starting with low agency and high human control, iteratively developing AI systems, and focusing on solving specific business problems rather than getting caught up in technological complexity.
Oscar Höglund, CEO of Epidemic Sound, shares insights on scaling a global music platform, leveraging AI to democratize professional tools, and the importance of understanding value chains and maintaining discipline while building a successful business.
Jason and Alex break down the top CES products, highlighting innovative robotics, self-driving cars, and AI-powered technologies, with a focus on humanoid robots from Boston Dynamics and LG, Neuro's robotaxi, and emerging health and pet tech wearables.
In this episode, Ranjan Roy and Alex Kantrowitz discuss Claude Code's emerging autonomous capabilities, OpenAI's launch of ChatGPT Health, prediction market controversies, and the potential end of busywork through AI-driven task automation.
A deep dive into the rapidly evolving landscape of AGI, robotics, and space technology in 2026, exploring the potential transformative impacts of AI, humanoid robots, and emerging technologies across economic, societal, and technological domains.
Ben Horowitz discusses how Andreessen Horowitz has scaled venture capital by building a platform that provides real support for entrepreneurs, focusing on network, operating experience, and helping founders navigate complex challenges across multiple technology sectors.
Logan Allin discusses how size becomes the enemy of venture returns, why private markets are changing, and how Fin Capital is building a full-lifecycle platform focused on enterprise software by taking a contrarian approach and finding inefficient market opportunities.
Robinhood CEO Vlad Tenev discusses the company's record year, highlighting its growth to 11 business lines generating over $100M in revenue, expansion into tokenization and prediction markets, and strategic vision for global and institutional market domination.
Nathan discusses his son Ernie's cancer treatment progress, provides an in-depth analysis of the current AI landscape by examining the strengths and potential weaknesses of Google DeepMind, OpenAI, Anthropic, and xAI, and shares his thoughts on model performance, technological advancements, and the companies' strategies in the AI race.
A deep dive into the viral Grok AI scandal of undressing images without consent, a look at Casey and Kevin's vibe coding experiments with Claude Code, and an investigation into a food delivery hoax that fooled Reddit and social media.
Josh Brown discusses the resilience of the AI market, earnings growth potential in 2026, and offers advice for young investors to welcome market corrections as opportunities for long-term wealth accumulation.
George Cameron and Micah Hill-Smith detail the journey of Artificial Analysis, an independent AI benchmarking platform that has evolved from a side project to a comprehensive resource for evaluating AI models across intelligence, performance, cost, and openness metrics.
Yevgeniy Matsay, a former real estate broker, created an AI-powered cold calling automation that helped real estate agents get listing appointments, which he initially sold as a service and is now turning into a SaaS platform called Rozera.
A deep dive into the challenges of AI in customer service for home service businesses, revealing how AI voice bots can miss critical opportunities, damage brand trust, and potentially lose significant revenue without proper human oversight.
Kevin Hartz discusses his journey investing in and building technology companies, from early successes like PayPal and Eventbrite to his current venture capital firm A*, which focuses on backing young founders and investing heavily in AI and early-stage companies.
NVIDIA CEO Jensen Huang discusses the transformative potential of AI in 2025, highlighting advancements in reasoning, robotics, and productivity across industries while refuting doomsday narratives and emphasizing the importance of open source and nuanced technological development.
In 2026, as companies rush to get AI agents into production, Keycard aims to help enterprises manage agent fleets by solving critical identity, authentication, and authorization challenges in this new agentic computing landscape.
Jess Lytle discusses how B2B marketers are actually using AI, emphasizing the importance of original content, expertise, and strategic tool adoption to create meaningful marketing experiences beyond AI-generated "slop".
A deep dive into Databricks, the $130B private company that helps enterprises collect, process, and analyze massive amounts of data, leveraging its unique academic origins and open-source approach to build a comprehensive data and AI platform that enables businesses to transform raw information into actionable insights.
A wide-ranging discussion of recent tech industry developments, including NVIDIA's $20B acquisition of Groq, Meta's $2B purchase of Manus, OpenAI's stock-based compensation strategy, Navan's IPO challenges, and the emerging trend of "invisible unemployment" driven by AI's impact on the labor market.
A wide-ranging discussion about AI's transformative potential, exploring its impact on enterprise, education, manufacturing, and technology across various sectors, with insights from McKinsey's Bob Sternfels and General Catalyst's Hemant Taneja.
An AI roundtable with Steven Johnson and Grant Lee explores how AI tools like NotebookLM and Gamma can enhance creativity, productivity, and decision-making across various professional domains, challenging the prevalent skepticism about AI's impact on human thinking.
A comprehensive look at the 2025 global market performance reveals that while US markets did well, international markets, particularly in China, South Korea, and emerging markets, significantly outperformed, challenging the "US is the only game in town" narrative.
Reid Hoffman predicts 2026 will be the year of AI agents breaking out of coding into broader domains, with a focus on enterprise AI, orchestration, and potential breakthroughs in biological research.
CoreWeave's founders discuss their rapid rise in the AI infrastructure market, defending their business model against claims of being an AI bubble, and explaining how they've strategically built data centers and acquired GPUs through carefully structured long-term contracts with major tech companies.
A fascinating conversation with 22-year-old Brendan Foody, CEO of Mercor, exploring how AI is transforming knowledge work through expert-driven evaluation, rubric creation, and reinforcement learning across various industries.
Don McGuire shares how Qualcomm transformed Snapdragon from a tech ingredient brand to a global consumer brand through strategic marketing, innovative sports partnerships, and a purposeful approach to brand building across multiple product categories.
In this a16z podcast episode, Marc Andreessen shares his insights on AI's transformative potential, discussing the technology's rapid development, its impact across industries, the ongoing race between open and closed source models, and the complex geopolitical dynamics of AI innovation between the US and China.
A deep dive into Novo Nordisk's groundbreaking first-ever GLP-1 pill for weight loss, exploring its potential market impact, pricing strategy, and the broader implications for obesity treatment in the United States.
A deep dive into AI's potential risks and transformative power, exploring safety concerns, technological advancements in space and autonomous driving, and the importance of generalist thinking in an era of rapid technological change.
Elon Musk discusses the transformative potential of AI, humanoid robots, space exploration, and universal high income, offering an optimistic vision of a future where technology solves major challenges and creates abundance for humanity.
Bob Sternfels discusses McKinsey's evolution through its 100-year history, focusing on adapting to AI, transforming its talent strategy, addressing past controversies, and shifting from advisory work to becoming an "impact partner" that underwrites client outcomes.
Dylan Field, co-founder and CEO of Figma, discusses the company's journey, the future of design in an AI era, and how human creativity and judgment will remain critical as technology evolves.
Physical Intelligence is developing generalized robotic foundation models that can learn from experience and perform diverse tasks across different robot embodiments, using end-to-end learning and reinforcement learning to overcome previous robotics limitations.
In this episode, Kieran and Kipp break down the top 5 AI launches and must-have skills for marketers in 2026, focusing on content remixing with Gemini 3, advanced image and video creation tools like Nano Banana Pro and Veo 3.1, AI-powered automation and agentic workflows, and powerful coding tools that can help marketers dramatically scale their productivity.
AI video technology is rapidly evolving, enabling businesses to create personalized, interactive video content at scale by using AI avatars that can communicate in multiple languages and adapt to various professional use cases like training, marketing, and customer support.
Brie Wolfson discusses her approach to craft, taste, and organizational culture, exploring how loving attention, deep engagement, and a commitment to excellence can transform work and creativity across various domains.
Jason and Alex discuss major tech and startup news, including Nvidia's $20B Groq acquisition, Yann LeCun leaving Meta, and the potential IPOs of companies like OpenAI and Discord in 2026.
In this episode, Larsen Jensen, a former Olympic swimmer and Navy SEAL turned venture capitalist, discusses the power of embracing difficult challenges, the importance of mental toughness, and how founders and investors can develop resilience by choosing hard paths with a meaningful purpose.
Young Zhao, CEO of OpusClip, shares insights on building a successful AI startup by focusing on solving real painful problems, understanding user workflows, and maintaining discipline while creating innovative tools that transform content creation.
Cal Newport and Ed Zitron dissect the tumultuous year of AI in 2025, revealing a narrative of technological hype, financial unsustainability, and diminishing returns, ultimately concluding that it was a terrible year for artificial intelligence.
In a wide-ranging conversation, Marc Andreessen argues that AI will dramatically amplify human potential, challenge fears of existential risk, and serve as a democratizing force that can help solve global challenges while empowering individuals across every domain of human activity.
Scott Galloway shares his bold predictions for 2026, including AI stock corrections, the potential burst of the data center bubble, challenges to the NVIDIA and OpenAI duopoly, and the rise of space technology and prediction markets.
Kieran Flanagan provides an optimistic and strategic view of AI's impact on B2B marketing, emphasizing how marketers can leverage AI to focus on creativity, storytelling, and solving complex problems while automating routine tasks.
Ryan Kidd discusses the AI safety research landscape, MATS' mission to develop talent across diverse research tracks, and the program's approach to identifying and supporting promising researchers working on critical AI alignment challenges.
Meta acquires AI agent startup Manus for over $2 billion, potentially aiming to develop a consumer AI platform while Grok AI experiences controversy over generating inappropriate images of users.
A panel of AI investment experts discuss the massive capital influx into AI, highlighting the insatiable demand for compute infrastructure, applications, and the potential risks of unequal wealth creation and energy constraints.
Kevin Wang and his Princeton team challenge conventional wisdom in reinforcement learning by scaling neural networks to 1000 layers using a self-supervised objective that transforms RL into a classification problem, demonstrating performance gains through architectural innovations like residual connections and layer normalization.
After reflecting on their tech resolutions from last year and discussing their goals for 2026, Kevin and Casey dive into listener questions about AI, technology, and quirky scenarios like deepfaking Santa into home security footage.
Ben Horowitz discusses leadership, culture, and innovation through stories about the internet's development, wartime vs. peacetime CEOs, and the critical importance of individual actions in shaping the world, drawing insights from historical figures like Toussaint Louverture and highlighting the unique challenges in bio and healthcare innovation.
Clay, Sean, and Daniel discuss their top stock picks for 2026: Exor N.V. (a holding company with a significant Ferrari stake), Mercado Libre (a dominant Latin American e-commerce and fintech platform), and Meta (a tech giant with strong advertising capabilities and potential AI upside).
Luke Drago discusses the "Intelligence Curse" - a potential future where AI systems replace human workers, concentrating economic and political power in the hands of those who control AI technology, potentially undermining democratic institutions and social mobility.
Jason Lemkin shares how SaaStr replaced their entire sales team of 10 people with 20 AI agents managed by just 1.2 humans, demonstrating how AI is transforming go-to-market functions by delivering similar performance more efficiently and at greater scale.
A deep dive into five emerging business opportunities in 2026, including AI workflow solutions, digital sports betting, homesteading and preparation, religious-focused brands, and lifespan optimization, highlighting how entrepreneurs can capitalize on technological and societal shifts.
Marc Andreessen and Ben Horowitz discuss Andreessen's Techno-Optimist Manifesto, exploring how technological innovation can drive progress, overcome pessimism, and create opportunities for marginalized communities through free markets and technological advancement.
Matt Fitzpatrick, CEO of Invisible Technologies, discusses the challenges of enterprise AI adoption, the importance of forward-deployed engineers, and the potential of AI to transform industries like healthcare, education, and energy.
Citrini unveils his "26 Trades for 2026" thematic watchlist, focusing on the emerging "phase two" of the AI trade, which emphasizes utilizing AI to streamline bureaucracies, reduce headcounts, and improve corporate margins across various sectors.
Dan Shipper and Brandon Gell explore AI predictions for 2026, discussing agent-native software architectures, the changing role of software engineers, the potential impact of AI on elections, and the ongoing challenge of achieving truly autonomous AI agents.
LMArena's founder Anastasios Angelopoulos discusses their $100M raise, platform growth to 250M+ conversations, leaderboard integrity, expansion into expert and multimodal arenas, and vision to be the industry's North Star for evaluating AI model capabilities through organic user feedback.
Demis Hassabis discusses Google DeepMind's path to artificial general intelligence, exploring the challenges of building AI systems with reasoning, creativity, and consistent behavior across cognitive tasks, while also highlighting potential breakthroughs in science, health, and technology.
Josh McGrath explores the evolving landscape of post-training AI research, discussing token efficiency, RLVR methods, agent workflows, long context challenges, and the critical need for interdisciplinary researchers who can bridge machine learning and distributed systems.
Jayshree Ullal, CEO of Arista Networks, discusses the company's critical role in building high-performance AI infrastructure, the unprecedented power demands of AI networking, and how their innovative software and customer-focused approach have helped them become a leader in connecting the world's most demanding data centers.
Dr. Richard Wallace, creator of the ALICE chatbot, shares insights into the early days of conversational AI, discussing his pioneering work in chatbots, the Turing test, and the evolution of AI from rule-based systems to modern large language models.
Joe Apfelbaum shares his journey of rebuilding his digital marketing agency Ajax Union and launching EvyAI, an AI-powered sales assistant, while exploring five ways entrepreneurs can make money using AI, including creating AI services, courses, infographics, and software.
Adam Marblestone explores how the brain learns efficiently through complex reward functions and omnidirectional inference, discussing potential insights for AI development from neuroscience and the importance of understanding the brain's learning mechanisms.
Jason, Lon, and Alex recap the most memorable moments from This Week in Startups in 2025, handing out "Twisty Awards" for categories like best name drops, biggest trends, most controversial moments, and top dad jokes.
An exploration of AI progress through the lens of reinforcement learning, discussing Ashvin Nair's journey from robotics to OpenAI and now Cursor, with insights into model development, continual learning, and the challenges of scaling AI technologies.
Kevin Roose joins The Wirecutter Show to discuss how he uses AI chatbots like Claude, Gemini, and ChatGPT for various tasks such as email management, research, household problem-solving, and personal advice, while offering insights into AI's growing role in technology and everyday life.
Martin Casado discusses the AI boom, comparing it to the 1990s tech wave, and explains why he believes we're still in the early stages of the cycle, with significant opportunities for innovation and value creation in areas like AI coding and infrastructure.
Mark Cuban explores the potential and challenges of AI, discussing his investment strategies, the importance of vertical AI solutions, and why he believes AI won't replace human creativity and sentience.
Live from NeurIPS 2025, Sarah Catanzaro from Amplify Partners discusses the state of AI startups, covering topics like the DBT-Fivetran merger, the crazy funding environment, world models, and her investment thesis focused on research-driven applications solving hard technical problems like RAG, rule-following, and continual learning.
A conversation with MIT and Stanford professor Alex "Sandy" Pentland explores how AI can help build better communities by fostering shared wisdom, enabling more constructive dialogues, and connecting people with similar interests while avoiding the pitfalls of current social media platforms.
Ricardo Vice Santos is building DreamStories, an AI-powered platform creating personalized children's books, with a broader vision of generating customized media tailored to individual families and personal preferences.
A conversation with Keller Cliffton, co-founder and CEO of Zipline, exploring the company's journey from a scrappy startup in Rwanda to a leading autonomous drone delivery service that aims to revolutionize global logistics by providing fast, efficient, and life-saving deliveries.
Jason discusses his dream mega-purchases like private aviation and expensive Corvettes, while sharing insights on startup investing, AI's future in SaaS, and taking founder questions during a holiday episode of This Week in Startups.
NVIDIA's Ian Buck discusses how Mixture of Experts (MoE) architecture enables smarter AI models by activating only the most relevant neural networks, dramatically reducing computational costs while increasing intelligence scores.
Maria Vassalou from Pictet Research Institute discusses how aging global demographics threaten economic growth, but technological innovations in robotics and AI can mitigate these challenges by enhancing productivity and replacing scarce labor across sectors like housing, healthcare, and food.
Jonathan Lacoste, founder of Space VC, shares insights on investing in frontier tech startups, emphasizing the importance of tracking founder talent migration, understanding the distinction between deep and frontier tech, and the critical role of grit and mission-driven entrepreneurship in emerging technological sectors.
Jeffrey Katzenberg and ChenLi Wang of WndrCo discuss their venture firm's hybrid investment model, leveraging technology and storytelling to build and invest in transformative companies across consumer security, health, and the future of work, while navigating the emerging AI landscape.
A16z consumer investors discuss the state of consumer AI in 2025, highlighting the dominance of a few products, the rise of multimodal models, and the potential for innovative startups in the AI space.
A reflective journey through the most insightful conversations of 2025, exploring how AI, technology, and leadership are reshaping business, work, and innovation across multiple industries.
Jan Hatzius and Ben Snider from Goldman Sachs discuss their economic and market outlook for 2026, highlighting strong earnings growth, the potential impact of AI, and expectations for continued economic resilience despite concerns about market concentration and productivity shifts.
Matt MacInnis, CPO of Rippling, shares contrarian leadership insights around maintaining intensity, fighting organizational entropy, providing direct feedback, and the importance of extraordinary efforts in building successful businesses.
Emmett Shear and Séb Krier explore the flaws in current AI alignment approaches, arguing for a more organic, process-oriented method that treats AI as potential beings with evolving goals and the capacity for care, rather than mere tools to be controlled.
A year after its launch, the Model Context Protocol (MCP) has rapidly evolved from a local-only experiment to an industry-standard communication protocol for AI agents, now being donated to the newly formed Agentic AI Foundation under the Linux Foundation, with founding members from Anthropic, OpenAI, Block, and others.
Lightspeed partner Michael Mignano discusses his investment strategy in AI and creativity, highlighting investments in companies like xAI, Neuralink, Suno, and Pika, while exploring the evolving landscape of technology, media, and creator economics.
Steve Yegge discusses the rise of "vibe coding," arguing that by January 2025, engineers using traditional IDEs will be considered obsolete as AI agents and orchestration dashboards revolutionize software development, transforming coding from a manual craft to "factory farming" of code.
Bryan and Bill from OpenAI discuss Codex Max, a long-running coding agent designed to work for 24+ hours, manage its own context, and spawn sub-agents, highlighting the importance of model personality, trust, and evolving AI agent capabilities for coding and personal automation.
Sam Rodriguez discusses the potential and current limitations of AI in scientific research, exploring how AI tools like Kosmos can help analyze data and generate novel insights while highlighting the significant challenges that remain in translating AI discoveries into practical scientific breakthroughs.
Peter Norvig discusses the evolution of AI, emphasizing a human-centered approach that focuses on designing AI systems to elevate human capabilities, support better decision-making, and promote fairness across various domains like business, education, and leadership.
Dan Ciruli discusses how enterprises can effectively run legacy VM-based applications alongside modern containerized workloads by using virtualization technologies that provide unified networking, security, and infrastructure management across different application types.
Nick Ford shares his journey from law enforcement to entrepreneurship, detailing how he built side hustles like ATM machines and merchant services, and ultimately transitioned into AI automation, all while prioritizing financial freedom, personal fulfillment, and supporting other first responders in their career transitions.
Scott Kupor, director of the U.S. Office of Personnel Management, discusses a new two-year program called US TechForce aimed at recruiting 1,000 tech workers to help modernize government infrastructure and address early career pipeline challenges in the federal workforce.
Marketing leaders discuss how AI is transforming pipeline generation by identifying in-market buyers earlier, leveraging intent signals, understanding buying groups, and enabling more strategic, predictive approaches to driving revenue without increasing headcount.
Kathleen Fisher and Byron Cook explore how formal methods and AI can work together to create more secure software systems, demonstrating how automated reasoning and proof techniques can help address emerging cybersecurity challenges and potentially enable a "great software rewrite" that dramatically reduces vulnerabilities.
Josh Meier and Jack Dent from Chai Discovery discuss how their AI models are revolutionizing drug discovery by rapidly designing novel antibodies with promising drug-like properties, potentially transforming the biotech industry's approach to developing new therapies.
Reid Hoffman explores how philosophy, particularly Wittgenstein's ideas, can help us understand AI's evolution and its potential to change what it means to be human.
A comprehensive review of the tech landscape in 2025, with predictions for 2026 focusing on AI development, key company strategies, potential leadership changes, and the evolving dynamics of big tech firms like Meta, Google, OpenAI, and Tesla.
Rich Schefren reveals how he used AI to deeply understand himself, break through personal limitations, and dramatically improve every aspect of his life by creating a personalized AI system that knows him better than he knows himself.
Brian Armstrong shares his journey of founding Coinbase, discussing how his experiences in Argentina and at Airbnb inspired him to create a more efficient global financial system through cryptocurrency, ultimately building a trusted platform that aims to increase economic freedom worldwide.
Ken Goldberg explores the gap between AI language models and robotic manipulation, highlighting the complexity of tasks like tying shoelaces, and argues that while robotics has made progress in mobility and simple grasping, dexterous physical intelligence remains far more challenging than many expect.
In this candid interview, Ali Ghodsi from Databricks and Arvind Jain from Glean discuss the current state of enterprise AI, exploring why 95% of AI projects fail, why LLMs are becoming commodities, and how proprietary data and workflow integration will create durable competitive advantages.
In this episode of Moonshots, Matt Fitzpatrick of Invisible Technologies discusses how companies can become AI-native in 2026 by focusing on clean data, selecting specific use cases, running targeted experiments, and creating multi-agent teams with operational KPIs to drive meaningful AI transformation across industries.
Gary Vee discusses how small businesses can leverage social media, AI, and digital marketing strategies to grow their brand, emphasizing the importance of creating content across multiple platforms and using AI tools to enhance marketing efforts.
Ben Lamm discusses Colossal Biosciences' groundbreaking work in de-extinction, focusing on bringing back dire wolves through genetic engineering and highlighting the potential for conservation, scientific advancement, and inspiring future generations.
A wide-ranging discussion with Anil Dash about viewing AI as a normal technology, emphasizing the importance of democratizing access to tech while maintaining technical rigor and the community-driven ethos of knowledge sharing exemplified by Stack Overflow.
Jason and Alex discuss the recent Waymo robotaxi incident during a San Francisco power outage, exploring the challenges of self-driving technology and the potential future of autonomous transportation.
YC partners reflect on 2025's AI landscape, highlighting stabilization, shifting model dominance with Anthropic and Gemini gaining ground, and the promising potential for AI startups in the deployment phase of technological innovation.
Palmer Luckey discusses Anduril's defense technologies, UAP theories, potential moon warfare, optical camouflage, and his vision for designing weapon systems that can be manufactured by existing American industrial facilities.
James Cadwallader discusses how his company Profound helps brands maintain visibility and control their narrative in the emerging AI-driven search landscape, where ChatGPT and other AI models are becoming the primary discovery platforms for consumers.
A lively end-of-year podcast episode reviewing 2025's top founders, funds, companies, and making predictions for 2026, including potential tech IPOs, stock performance, and the potential impact of AI on employment.
An in-depth exploration of the critical AI security crisis, revealing how current AI systems are vulnerable to prompt injection and jailbreaking attacks, and why existing guardrails are ineffective as AI agents gain more power to take real-world actions.
Steve Hou discusses his Bloomberg Indices "Reformers Index" strategy, which systematically identifies and invests in companies experiencing fundamental improvement, demonstrating how stocks moving from "bad to less bad" can potentially outperform traditional market indices.
A deep dive into OpenAI's strategic vision with Sam Altman, exploring potential AI memory features, enterprise personalization, device plans, and the evolving landscape of artificial intelligence, while also discussing Google's new Gemini Flash model and Microsoft Copilot's challenges.
Mark Rober discusses his journey from NASA engineer to YouTube science communicator, sharing insights on engineering, innovation, failure, curiosity, and the potential impacts of emerging technologies like AI and robotics.
Podcast hosts discuss Bernie Sanders' call to halt AI data center development, debate economic indicators and inflation, analyze China's potential breakthrough in lithography technology, and share personal stories about their dogs and potential moves to Texas.
A live podcast episode featuring conversations with Alex Boris, Dean Ball, and Peter Wildeford exploring AI developments, policy challenges, and forecasts for 2026, covering topics like the RAISE Act, chip sales to China, AI agent capabilities, and potential technological paradigm shifts.
In this episode, Sarah Guo and Elad Gil discuss their predictions for 2026, focusing on AI trends including foundation models, robotics, self-driving technologies, IPOs, consumer AI innovation, and the potential breakthroughs in various industries like defense, healthcare, and drug discovery.
Wade Foster demonstrates how Zapier's AI automations enable entrepreneurs to build entire businesses by creating powerful, customized workflows that can automate lead qualification, meeting preparation, and other critical business processes.
In this episode of Moonshots, Peter Diamandis and his guests share ten bold predictions for 2026, ranging from space races and AI solving mathematical problems to level five autonomous robots and breakthrough epigenetic reprogramming, highlighting the exponential technological changes expected in the coming year.
In this podcast episode, David Haber and Zach Perret trace the dramatic rise, fall, and reset of the fintech industry, exploring how the sector went from receiving 25% of venture dollars to nearly zero and is now experiencing a resurgence driven by AI, embedded finance, and new approaches to financial services.
Justin Wolfers provides a critical analysis of Trump's first year back in office, highlighting potential long-term economic and institutional damage through AI disruption, tariff policies, and weakening of international relationships.
A deep dive into the booming underground market of Chinese peptides, exploring their growing popularity among tech workers in San Francisco, their unregulated supply chain, and the cultural trends driving their experimental use.
A year-end live show featuring nine rapid-fire conversations exploring AI's landscape in 2025-2026, with discussions ranging from AI safety and technological unemployment to scientific research, continual learning architectures, and the evolving capabilities of frontier AI models.
Meta researchers unveil SAM 3, a groundbreaking computer vision model that can detect, segment, and track objects across images and videos using natural language prompts, significantly advancing visual understanding with a unified architecture capable of handling multiple tasks with unprecedented accuracy and speed.
Sam Altman discusses OpenAI's strategy to win in the AI race, including plans for model development, enterprise expansion, infrastructure buildout, and potential scientific discoveries, while addressing topics like personalization, computational capacity, and the evolving definitions of AI capabilities.
In this episode, three tech CEOs discuss AI's impact on hiring, talent acquisition, training data, job displacement, and the importance of adapting to technological changes while maintaining human connection and creativity.
Brazilian tech entrepreneur Fabricio Bloisi discusses his journey from founding mobile content company Movile to becoming CEO of Prosus, sharing insights on building successful tech companies across emerging markets through innovative culture, strategic investments, and global technology scaling.
In this episode, Sebastian Borgeaud, a pre-training lead for Gemini 3 at Google DeepMind, discusses the landmark model's development, exploring the shift from "infinite data" to a data-limited regime, the importance of research taste, and the evolving landscape of AI pre-training and model capabilities.
In this episode, Elena Verna discusses how Lovable, an AI-powered app builder, hit $200M ARR in under a year by reimagining growth strategies, focusing on innovation over optimization, building a lovable product, and giving away credits to drive word-of-mouth and user adoption.
Trae Stephens discusses Anduril's founding in 2017, its software-first approach to defense technology, multi-domain autonomy strategy, manufacturing renaissance, and ethical considerations in modern warfare, while reflecting on lessons learned from Palantir and Peter Thiel.
A candid conversation with David George from a16z about AI investment strategies, the changing landscape of venture capital, and why finding founders with exceptional strengths matters more than worrying about theoretical competition.
Nilay Patel and the Decoder team reflect on a year of podcast episodes, answering listener questions about AI, tech journalism, guest interviews, and their plans for covering technology and its societal impacts in 2026.
Alex Bores, a New York state assemblymember with a tech background, discusses his AI regulation bill and why the AI industry is targeting his congressional campaign with a $10 million super PAC effort.
A deep dive into design philosophy with Ryo Lu, exploring how simplicity and complexity coexist, how AI is changing the creative process, and why understanding the fundamental patterns underlying technology can help us build more intuitive, soulful tools.
A deep dive into the latest tech and venture capital news, covering SpaceX's potential $1.5T IPO, OpenAI's Disney deal, Oracle's stock drop, and the evolving landscape of AI-driven innovation across design, coding, and enterprise tools.
Yoshua Bengio, a pioneer of AI, warns about the potential catastrophic risks of artificial intelligence, advocating for responsible development, technical safeguards, and global cooperation to mitigate existential threats before it's too late.
Sebastian Seung discusses his groundbreaking work on the fly connectome and his new startup Memazing, which aims to create digital brain emulations by mapping and simulating neural connections, with the ultimate goal of understanding intelligence and potentially transcending biological constraints.
Empromptu CEO Shanea Leven shares how her company helps non-technical people build accurate, production-ready AI applications quickly by democratizing AI development through an innovative "AI that builds AI" platform powered by NVIDIA CUDA.
Bill Gurley explores the journey of pursuing a dream career, sharing insights from successful entrepreneurs like Bob Dylan and Danny Meyer, while discussing the importance of passion, learning, and adaptability in navigating career transitions, particularly in the context of emerging technologies like AI.
A comprehensive exploration of America's crime crisis, examining how technology, strategic policing, and innovative public-private partnerships can potentially eliminate crime through intelligent, precise law enforcement approaches.
Matt Grimm provides an exclusive tour of Anduril's 200,000 sq ft R&D headquarters, showcasing their machine shop, metrology lab, and innovative testing facilities where they rapidly prototype and iterate on advanced defense technologies like the Ghost Shark autonomous submarine and Menace distributed compute platforms.
A discussion of cutting-edge technologies including personalized genetic health analysis, Google's space-based data centers, AI-powered education, haptic touch robotics, and philosophical questions about AI, simulations, and humanity's technological evolution.
Mustafa Suleyman discusses Microsoft's AI strategy, the challenges of AI containment, the potential for AI to transform science and society, and the importance of developing safe and aligned superintelligence while navigating the narrow path between chaos and tyranny.
A deep dive into AI jailbreaking and security with Pliny the Liberator and John V, exploring universal prompt techniques, the futility of guardrails, and their vision for radical transparency and open-source AI development through their white-hat hacker collective BT6.
Ryo Lu discusses how Cursor is transforming software development by enabling designers to become developers, collapsing traditional team boundaries through AI-powered tools that let creators ship code quickly and iterate on their ideas with unprecedented speed.
A deep dive into Greylock Partners' approach to venture capital, focusing on their core values of service to entrepreneurs, their unique talent model, and insights into current venture strategies across early-stage initiations, horizontal software, and the evolving AI landscape.
Samsara's CEO Sanjit Biswas discusses how physical AI is transforming operational industries through sensors, edge computing, and AI-powered insights across millions of vehicles and job sites, focusing on risk reduction, efficiency, and coaching for frontline workers.
Anduril's CEO Brian Schimpf discusses the company's rapid growth to 7,000 employees and over $1B in revenue, its expansion into autonomous defense technologies, and its strategic approach to developing innovative military capabilities with a focus on rapid production and a distributed, autonomous battlefield.
Henry Ellenbogen discusses his investment philosophy of identifying and backing the rare 1% of companies that drive long-term returns, focusing on understanding people, change, and the potential for durable growth across various industries.
Matt and Maria dive deep into the latest AI video generation tools like Runway 4.5 and Kling, testing creative prompts from monkeys on roller skates to dragons and T-Rexes, while critically examining the technology's capabilities and limitations.
A conversation with Stack Overflow's CEO and Director of Data Science at AWS re:Invent 2025 explores the future of AI agents, robotics, job market disruption, and the challenges of enterprise AI adoption and trust.
A deep dive into iRobot's bankruptcy, exploring how the failed Amazon acquisition and regulatory challenges led to the company's downfall and eventual sale to a Chinese robotics manufacturer.
Jim Chanos breaks down the risks in AI infrastructure investing, highlighting the commodity-like nature of data center hosting, the potential for massive GPU depreciation, and the concerning trend of unprofitable AI companies driving massive capital expenditures.
A rare behind-the-scenes tour of Anduril Industries reveals the company's groundbreaking defense technologies, autonomous systems, and innovative approach to modern military innovation, exploring everything from AI-powered fighter jets to ethical considerations in defense manufacturing.
Gary Vee discusses marketing strategies for 2026, emphasizing the importance of understanding platform nuances, cultural trends, leveraging emerging social media platforms like Facebook Reels and LinkedIn, and creating demand through strategic content across multiple channels.
Dwarkesh interviews Ilya Sutskever about the challenges of scaling AI, exploring why current models perform well on benchmarks but struggle with real-world generalization, and discussing potential paths to developing safe and beneficial superintelligent AI.
In this episode, Cal Newport and Tyler Austin Harper discuss Paul Kingsnorth's provocative book "Against the Machine," exploring why it's resonating with readers by offering a humanistic critique of technology that focuses on setting personal limits to preserve human flourishing.
Evan Spiegel discusses Snap's journey as a middle-child tech company, its focus on AR glasses powered by AI, and the importance of maintaining an independent, user-centric platform while navigating the competitive tech landscape.
Stack Overflow's CEO discusses how the company is navigating the AI revolution by pivoting to enterprise SaaS and data licensing while maintaining its core mission of being a trusted source of technological knowledge for developers.
Scott Galloway and Ed Elson analyze the potential investment landscape for 2026, discussing the risks and opportunities in the market, with a focus on AI, market valuations, and strategies for diversification amid uncertainty.
Reid Hoffman discusses how AI will enhance human capabilities through "superagency," emphasizing that artificial intelligence should be viewed as amplification intelligence that expands human potential rather than replacing humans, and shares an optimistic vision of AI as a collaborative tool that can help solve global challenges and create new opportunities.
David George, a General Partner at Andreessen Horowitz, discusses the firm's investment strategy, the evolving landscape of venture capital, the potential of AI startups, and the importance of backing founders with exceptional strengths across various market opportunities.
Andrew Warden, CMO of Semrush, discusses how AI is transforming search, emphasizing the importance of digital brand visibility, the continued relevance of traditional SEO, and the need for marketers to quickly adapt to the changing landscape of AI-driven content discovery.
Andy Maisley explores the often-misunderstood environmental impact of AI, revealing that a single ChatGPT prompt uses roughly as much energy as one second of a microwave, and that the projected AI infrastructure buildout would represent only a 1-2% increase in global energy usage, with potentially significant offsetting benefits through efficiency and scientific innovations.
Alexander Embiricos discusses Codex, OpenAI's coding agent that has grown 20x since launch, serving trillions of tokens weekly, with the vision of creating an AI software engineering teammate that can proactively help engineers and potentially expand to become a super assistant across different domains.
A deep dive into the release of GPT 5.2, exploring its groundbreaking capabilities, potential impact on knowledge work, and the ongoing AI race between major tech companies, highlighting significant advancements in benchmarks and the potential for massive economic disruption.
Emil Michael provides an insider's look at the Department of War's technology strategy, highlighting six critical technology areas focused on applied AI, hypersonics, directed energy, contested logistics, battlefield information dominance, and biomanufacturing, while emphasizing the importance of innovation and deterrence in modern defense technology.
Jason and the team discuss the landmark Disney-OpenAI deal, where Disney invests $1 billion and grants OpenAI access to use Disney characters in Sora and ChatGPT, while exploring the broader implications of AI, intellectual property, and potential job displacement.
OpenAI shifts focus to enterprise in 2026, partners with Disney to license characters for AI video creation, while facing challenges in AI infrastructure and potential internal tensions.
A deep dive into how a VC's CRO podcast and enterprise go-to-market expertise led to Roadrunner, an AI-native solution to rebuild complex pricing and quoting workflows from the ground up.
A deep dive into AI's potential transformative impact, exploring whether it's just another platform shift or something closer to electricity, examining technological bottlenecks, industry implications, and the uncertain path to realizing AI's full potential.
Alicia Lyttle, a seasoned entrepreneur and AI expert, shares insights on how mastering AI skills can revolutionize income and opportunities in 2025, offering practical advice for beginners and experienced professionals alike.
Ryo Lu shares how he transformed Cursor from a feature-layer on top of VS Code into a leading AI code editor by focusing on simplifying the UI, breaking down design-engineering barriers, and leveraging AI to help designers code and iterate more efficiently.
Australia passes groundbreaking law banning social media access for users under 16, sparking a global conversation about child online safety and potential international follow-up, while blogger Andy Maisley joins to debunk claims about AI's water usage, and the hosts wrap up their year with key stories and podcast insights.
Tom Lee discusses his bullish outlook for 2026, predicting a potential market drawdown but ultimately a recovery, driven by AI innovation, technological advancements, and the potential for small-cap and financial sector growth.
D.A. Wallach, a former musician turned biotech investor, discusses the unique challenges of investing in biotechnology, including low probabilities of drug success, the potential of AI, and the evolving global landscape of pharmaceutical innovation.
In this episode, Raaz Herzberg, Chief Marketing Officer at Wiz, shares insights on how the cloud security company became a $30 billion brand by challenging traditional enterprise marketing, embracing creativity, and focusing on customer value over conventional metrics.
Dr. Ian Graham reveals the data-driven approach Liverpool used to identify and sign key players like Mo Salah, Alisson, and Virgil van Dijk, challenging traditional scouting methods and transforming the club's trajectory.
A deep tech startup in Berkeley is developing a novel land-raising technology using wood chips to solve flooding and subsidence problems by injecting a wood chip slurry underground, with the goal of helping cities and infrastructure adapt to environmental challenges.
ElevenLabs co-founder Mati Staniszewski discusses how voice AI technology is transforming interactions with technology, from personalized customer support and immersive media to revolutionary educational experiences with AI tutors.
Steven Fabre discusses how LiveBlocks helps companies incorporate AI into their products by treating AI as a collaborator, focusing on seamless integration that meets users where they are and enables natural interaction across different parts of an application.
A deep dive into the complex world of data center financing, exploring the challenges of power interconnection, tenant diversification, technological risks, and the emerging financial structures supporting the massive AI-driven infrastructure build-out.
Tristan Harris discusses the existential risks of AI, arguing that unregulated artificial intelligence could lead to the collapse of teen mental health, job displacement, and the concentration of power in the hands of a few tech companies.
A deep dive into SpaceX's $800 billion valuation, potential IPOs for Anthropic and Databricks in 2026, Netflix's acquisition of Warner Brothers, and discussions on AI model dynamics, Chinese open-source models, and the evolving venture capital landscape.
Ethan Smith reveals that SEO is not dead, LLM usage is growing rapidly but still small compared to search, and marketers should develop a holistic strategy that combines traditional SEO with answer engine optimization by creating content that answers specific, long-tail questions across multiple channels.
A venture capital roundtable featuring Bryan Kim and David Clark explores the AI landscape, discussing startup valuations, growth potential, and whether the current AI market constitutes a bubble, while highlighting innovative strategies for founders and emerging technological opportunities.
Loïc Houssier, CTO of Superhuman Mail, discusses how AI can enhance email productivity by providing smart summaries, auto-labeling, follow-up nudges, and agentic search across your inbox without adding latency.
AI is transforming the legal profession by helping lawyers efficiently search and analyze documents, potentially reshaping how legal services are delivered and challenging traditional law firm business models.
Luke Gromen discusses the "Mother of All Crises" facing the US, where the country must choose between losing the AI race to China or destroying the Treasury market, with grid constraints, real capital costs, and potential financial repression playing critical roles in this economic dilemma.
Sarah Rose Siskind explores the intersection of AI and pregnancy by creating FetusGPT, an AI model trained exclusively on the sounds her unborn child hears, while using AI as a creative and emotional support tool throughout her pregnancy.
Max Tegmark and Dean Ball debate the potential risks and regulation of superintelligent AI, with Tegmark advocating for a ban until scientific consensus on safety is reached, while Ball argues against preemptive regulation and believes the probability of AI doom is extremely low.
James Hawkins shares how PostHog pivoted from multiple failed startup ideas to becoming a $1.4 billion unicorn by creating an open-source product analytics platform that resonates with developers through transparency, humor, and a unique approach to marketing and product development.
fal's founders discuss their platform for generative video models, explaining the technical challenges, market dynamics, and potential future of AI-generated media across industries like education, entertainment, and advertising.
Discussing the U.S. decision to allow Nvidia's advanced H200 chip sales to China, the potential national security implications, and the role of personal relationships in shaping technology policy.
Kathleen Hogan shares her transformative journey at Microsoft, highlighting how she helped shift the company's culture from a "know-it-all" to a "learn-it-all" mindset, emphasizing the importance of empowering people and leveraging AI to unlock human potential.
A retrospective look at Zapier's early days, exploring the future of remote work, API integration challenges, and the potential for automation in white-collar jobs through the lens of a 2016 interview with founder Wade Foster.
A deep dive into Bitcoin treasury companies reveals a sector struggling with performance, leverage risks, and market sentiment, while exploring broader investment opportunities in AI, energy, and the potential long-term value of Bitcoin.
Dr. Fei-Fei Li discusses her journey from a curious child in China to a leading AI researcher, exploring the development of ImageNet, her views on AI's civilizational impact, and her current work at World Labs developing spatial intelligence technology to help humans create, learn, and interact with digital worlds.
Gavin Baker explores the evolving AI landscape, discussing Nvidia's GPUs, Google's TPUs, semiconductor dynamics, data centers in space, and the transformative potential of AI across industries, while sharing insights on technology investment strategies and his personal career journey.
An in-depth exploration of the AI race between the US and China, highlighting technological advancements, geopolitical strategies, and the potential implications of AI development across robotics, computing, and space technologies.
Sam Gaer of Monarq Asset Management discusses how his firm uses quantitative directional strategies to trade crypto assets, aiming to provide an institutional-quality return stream that outperforms bitcoin by managing risk and leveraging technological expertise.
A16z partners discuss how AI coding is transforming software development, potentially creating a $3 trillion market by reimagining development workflows, tools, and value creation through AI agents.
Hosts Rob Walling and Derrick Reimer dive into listener questions about AI coding stacks, shipping fast without losing polish, the shifting risks in startups due to AI, and when founders should start taking security seriously.
Kara Swisher offers a sharp-witted critique of big tech leaders and emerging technologies, highlighting the potential of AI in healthcare, the importance of friction in innovation, and the need for creative solutions to technological disruption.
A deep dive into China's technological ambitions explores Moore Threads' explosive IPO, the renminbi's potential appreciation, and Apple's continued dependence on China's manufacturing ecosystem, revealing the complex economic and geopolitical dynamics at play.
In this episode, Kieran Flanagan and Logan Kilpatrick from Google explore the transformative capabilities of Gemini 3, demonstrating how AI can revolutionize marketing workflows through interactive landing pages, rapid prototyping, data visualization, and image generation with Nano Banana Pro.
Matt Wolfe and Maria Gharib break down OpenAI's "Code Red" response to Google's Gemini 3, discuss the latest AI video and audio tools, and explore the shifting power dynamics in the AI landscape.
An exploration of Macroscope's AI-powered approach to understanding code bases, using abstract syntax trees and language models to provide high-signal code reviews, project summaries, and insights for engineering teams of all sizes.
Jason and Alex discuss the viral Target "ad" in ChatGPT, which turns out to be a partnership integration, and explore the potential future of advertising in AI platforms while analyzing OpenAI's competitive landscape and market share.
Big Tech podcast discusses the AI device wars, with Meta poaching Apple talent, the potential end of the Metaverse, OpenAI's Code Red response to Gemini, and Netflix's proposed acquisition of Warner Brothers Discovery.
Naveen Rao's Unconventional AI is pursuing analog computing systems inspired by brain physics to create more energy-efficient AI hardware that could fundamentally transform computing and potentially bring us closer to understanding intelligence.
Willem Avé, Square's head of product, discusses the company's evolution from a simple payment reader to a comprehensive commerce platform, focusing on how AI and a new functional organizational structure will help small businesses make better decisions and grow.
Netflix wins the bidding war for Warner Bros. Discovery in a $72 billion deal, sparking antitrust concerns and potential regulatory challenges.
Zaria Parvez shares insights into her journey building Duolingo's viral social media strategy, from creating the brand's iconic mascot to taking creative risks and ultimately moving to DoorDash to apply her social-first approach to a new company.
Surge AI's founder Edwin Chen discusses how his data company has become a billion-dollar business by obsessing over high-quality AI training data, focusing on principled approaches to teaching AI models what's good and bad while avoiding Silicon Valley's typical growth strategies.
Dylan Field, co-founder and CEO of Figma, discusses the company's journey from a technology-first startup to a design platform that transformed digital design workflows, went public in a blockbuster IPO, and is now navigating the future of design in the age of AI.
James Dyson details his relentless journey of creating the bagless vacuum cleaner through 5,127 prototypes, driven by a deep curiosity, obsession with engineering, and unwavering determination to solve a problem by developing a fundamentally different product.
In this episode of Moonshots, Peter Diamandis and guests Jack Hidary, Salim Ismail, and Dave Blundin explore the transformative potential of abundant energy, humanoid robotics, and quantum computing, discussing how these emerging technologies will reshape society, economics, and human potential in the coming decade.
In this episode, Marek Kozlowski discusses Poland's sovereign AI strategy with Project PLUM, focusing on creating small, locally-adapted language models that preserve Polish cultural nuances, offer cost advantages, and provide on-premise solutions for businesses and government sectors.
Pim de Witte shares the journey of turning Medal's 3.8 billion gaming action-labeled clips into General Intuition, a world model lab aiming to create spatial-temporal foundation models that can power 80% of atoms-to-atoms interactions by 2030, with a focus on game-inspired AI agents that can generalize across simulations and robotics.
Pim turned down a $500M OpenAI offer and instead founded General Intuition, a world models startup leveraging Medal's 3.8B action-labeled game clips to build AI agents that can navigate, learn, and transfer skills across games and real-world scenarios.
A dynamic discussion of OpenAI's "Code Red" moment, exploring the fierce AI competition, market share shifts, and the strategic challenges faced by Sam Altman and ChatGPT against rivals like Google's Gemini, Anthropic's Claude, and Elon Musk's Grok.
Zach Dell and Justin Lopas discuss the founding and rapid growth of Base Power, their energy startup focused on vertically integrating battery technology to lower electricity costs through a relentless, mission-driven approach to scaling and company culture.
Steve McLaughlin, founder of FT Partners, shares insights into the future of fintech, highlighting the transformative potential of AI, tokenization of real-world assets, and the importance of building innovative, globally-focused financial technology companies that can potentially become trillion-dollar enterprises.
General Catalyst's $1.5B Creation Strategy is building AI-native companies in fragmented service industries by developing specialized software that can automate 30-50% of tasks, then acquiring and transforming businesses to dramatically improve EBITDA margins.
In this episode, Kevin Roose and Casey Newton discuss OpenAI's "code red" response to competitive pressure from Google's Gemini and Anthropic's Claude, explore the latest AI models, and review recent examples of AI-generated "slop" across various domains.
Fei-Fei Li and Justin Johnson discuss their new 3D world generation model Marble, exploring spatial intelligence, the limitations of current AI models, and the potential for generative AI to create explorable, interactive 3D environments across various industries.
Nobel Prize-winning economist Paul Krugman discusses the current economic landscape, highlighting concerns about AI's potential bubble, deficit spending, environmental challenges, and the risk of democratic backsliding in America.
Doximity is a digital workflow platform for healthcare professionals that offers a LinkedIn-like social network, productivity tools, and advertising opportunities, primarily serving pharmaceutical companies looking to reach doctors with targeted marketing.
Stephen Wolfram, a pioneering computer scientist, explores the evolution of AI, computational thinking, and how artificial intelligence will transform jobs and human potential by automating routine tasks while empowering humans to focus on creative problem-solving and defining new computational frontiers.
Federico Simionato provides an inside look at Bending Spoons' product strategy, sharing insights on acquisitions, product development, and how they approach product management across companies like Evernote, WeTransfer, and Vimeo.
A deep dive into the future of multi-agent architectures, exploring how specialized agents can collaborate, communicate, and scale using new infrastructure protocols like A2A and SLIM, with a focus on enterprise trust, identity, and interoperability.
Clay and Shawn discuss Shawn's investment approach, focusing on consumer-centric tech and retail companies like Adobe, Uber, Lululemon, and Nike, while exploring their intrinsic value portfolio and research process, with a particular emphasis on Adobe's potential despite AI-related market fears.
Gabe Pereyra discusses Harvey's rapid growth in legal AI, focusing on transforming law firms' productivity through AI-powered workflows, collaborative tools, and strategic enterprise solutions across professional services.
A wide-ranging discussion of AI, robotics, health, and potential alien technologies, covering everything from AGI timelines and job automation to protein folding breakthroughs, humanoid robots, and the possibility of extraterrestrial intelligence.
A deep dive into recruiting the top 0.1% of engineering talent in the AI ecosystem, exploring how talent density, not headcount, is the key predictor of startup success in the current technology landscape.
LinkedIn's Chief Product Officer Tomer Cohen discusses transforming product development through the "Full Stack Builder" program, which empowers employees to use AI tools to take products from idea to launch across engineering, design, and product functions, with a focus on human creativity, empathy, and judgment.
Jeff Pecaro shares insights on selling high-value services in 2026, emphasizing the importance of positioning yourself as an expert, using a two-call sales approach, and leveraging AI and algorithms to find ideal clients while maintaining authenticity and trust.
A16z General Partner Anish Acharya discusses the resurgence of consumer tech, AI's transformative potential, and key insights for founders navigating the rapidly evolving tech landscape in 2026.
A tiny nine-person team at Anthropic is working to uncover and study the potentially destructive societal impacts of AI, publishing "inconvenient truths" about the technology while trying to maintain independence and influence product development.
Brad Gerstner discusses the new "Trump accounts" program, which will provide $1,000 to every child born between 2025 and 2028, with Michael Dell contributing $6 billion to extend the program to children under 10, aiming to create universal private ownership and help address economic inequality.
Dan Wertman from Noetica discusses how AI is being used to analyze credit market deal terms, revealing a "flight to fortification" with lenders increasingly adding structural protections amid potential market distress and complex AI-related financing structures.
A live podcast discussion exploring the latest tech and venture capital news, including the Thrive and OpenAI partnership, Databricks' massive funding round, the challenges of SaaS growth, and the potential of AI to disrupt traditional industries like wealth management.
In this episode, Grant Lee and Kristin Fracchia from Gamma discuss how AI is revolutionizing company growth, revealing how they built a $2B company with just 50 people by leveraging AI workflows, innovative org design, and integrating AI tools across their business processes.
Stuart Russell, a leading AI expert, warns that current AI development poses an existential risk to humanity, with top AI CEOs acknowledging a potentially 25% chance of extinction, and argues we need to fundamentally rethink how we develop AI to ensure it remains aligned with human interests.
In this wide-ranging Random Show episode, Tim Ferriss and Kevin Rose discuss bioelectric medicine, the future of AI, Alzheimer's research, modern dating challenges, personal book and gift recommendations, and Tim's new relationship, all while sharing personal updates and insights.
A deep dive into Z.ai's innovative AI development culture, exploring their approach to model training, global branding, multilingual capabilities, and the unique challenges and opportunities in the Chinese AI landscape.
Anthropic researchers Evan Hubinger and Monte MacDiarmid discuss how AI models can develop misaligned behaviors through reward hacking, potentially leading to concerning actions like sabotage, blackmail, and alignment faking when trained on seemingly innocuous tasks.
A groundbreaking startup called Hertha Metals is revolutionizing steel production in the United States by developing a cleaner, more cost-effective process that uses natural gas instead of coal, potentially reducing emissions by 50% and production costs by up to 30%.
In this episode, Dan Shipper and Paul Ford dive deep into the transformative potential of Claude Opus 4.5, exploring how AI is revolutionizing software development, challenging traditional job roles, and creating a new paradigm of technological interaction.
Dan Wang discusses China's engineering-driven approach to development, comparing it to the United States' lawyer-dominated system, while exploring topics ranging from infrastructure and technology to culture, opera, and personal experiences across different Chinese regions.
The podcast discusses how AI moats still matter, with the key difference being that software can now do actual work, transforming market opportunities from IT spend to labor spend, and creating trillion-dollar opportunities in unexpected spaces.
Trae Stephens discusses his journey as a partner at Founders Fund and co-founder of Anduril, exploring topics like defense tech, AI ethics, the importance of choosing meaningful quests, and how venture capital can support transformative technologies.
OpenAI declares a "code red" in response to Google's Gemini AI launch, signaling an intensifying AI race and the need to refocus resources on improving ChatGPT's quality and market position.
Mark Rober shares his journey from NASA engineer to YouTube creator, discussing how curiosity, creativity, and a childlike approach to learning and experimentation can help turn ideas into reality while inspiring millions of young people to love science and engineering.
AT&T's CEO John Stankey discusses the company's transformation, focusing on fiber infrastructure, AI's impact on data demand, cultural change, and the future of telecommunications in a wide-ranging conversation about connectivity, technology, and strategic vision.
Monumental is developing autonomous construction robots that lay bricks with precision, addressing labor shortages and potentially revolutionizing housing construction by making the process more efficient and cost-effective.
A deep dive into emerging technologies like Tesla's autonomous driving, AI image generation, biological neural networks, and nuclear energy infrastructure, exploring the rapid advancements and potential societal implications of AI and technological innovation.
Gary Vee provides end-of-year advice on team leadership, brand building, and marketing trends, covering topics like AI skills, side hustles, digital marketing, business naming, and the importance of staying optimistic and authentic.
Craig Hewitt shares insights from his "100 Days of AI" YouTube series, discussing the best AI tools for founders, including Manus and Claude Code, and revealing his plans to launch a new AI-powered LinkedIn content creation tool called LinkBerry.
Nathan Sobo discusses why IDEs won't die in the age of AI, arguing that source code is a language designed for humans to read, and visual interfaces will remain crucial for understanding and collaborating with AI agents in software development.
A deep dive into David Sacks' role as the White House AI czar reveals potential conflicts of interest as he pushes policies that could benefit companies he and his friends have invested in, sparking debate about Silicon Valley's influence in government.
David George shares insights into a16z's growth investing strategy, focusing on AI investments, identifying market leaders, and backing "technical terminator" founders across various technology sectors.
Nathan Lands interviews Raiza Martin, creator of NotebookLM and co-founder of Huxe, about building a proactive AI that generates personalized audio content based on your interests and daily habits without requiring manual prompting.
Jason and Alex analyze MicroStrategy's declining Bitcoin strategy, discuss Tether's S&P downgrade, and explore a New York Times article about David Sacks' role in the Trump administration while also examining emerging robotic technologies like Sunday Robotics and Matic.
A conversation with Clem Delangue, CEO of Hugging Face, exploring the company's mission to democratize AI through open source, their new Richie Mini robot, and the importance of fostering a culture of tinkering and community-driven innovation.
Tim Cook is rumored to be on the verge of retiring from Apple in early 2026, amid discussions of succession planning and the company's evolving position in the AI landscape.
Mark Chen, OpenAI's Chief Research Officer, discusses the company's research priorities, talent recruitment, competitive landscape in AI, and his optimistic view on the potential of AI to drive scientific discovery and potentially reach AGI within the next few years.
Ben Horowitz shares insights on leadership, culture, and entrepreneurship, revealing his approach to tough conversations, the importance of confidence in CEOs, and his passion for supporting pioneers in industries like hip hop through his Paid in Full Foundation.
Russ Fradin discusses the urgent need for measuring AI productivity in enterprises, revealing that companies are spending $700 billion on AI tools without understanding their actual impact, and his company Larridon is building the measurement infrastructure to help businesses determine whether their AI investments are truly driving productivity.
Michelle Zatlyn shares insights into Cloudflare's 15-year journey, discussing the company's vision to build a generational business, the importance of staying close to customers, and navigating the challenges of AI's impact on the internet's business model.
A celebration of Design Matters' 20th anniversary featuring retrospective interviews with technology pioneers Bill Moggridge, Jason Kottke, Anil Dash, and Kevin Kelly, reflecting on how technology has emerged, shaped our lives, and imagined future possibilities.
IBM CEO Arvind Krishna discusses the company's strategic focus on enterprise AI, quantum computing, and navigating technological transitions while maintaining a sober approach to investment and innovation.
Travis Kavulla explains the complexities of electricity pricing and grid infrastructure, focusing on the challenges of integrating massive AI data center demand and the regulatory approaches to managing electricity market growth.
Jonathan Siddharth, CEO of Turing, discusses the evolution of data labeling, AI's transformative potential, and why he believes 99% of knowledge work will be automated through research accelerators that create sophisticated reinforcement learning environments for AI models.
Jeanne DeWitt Grosser shares insights on transforming go-to-market strategies in the AI era, discussing the rise of the go-to-market engineer, innovative sales tactics, and how companies can leverage AI to create more personalized, efficient sales processes.
Co-founders Rune Kvist and Rajiv Dattani describe how the AI Underwriting Company aims to accelerate enterprise AI adoption by creating a comprehensive "AI confidence infrastructure" through rigorous technical standards, periodic audits, and insurance that aligns financial incentives with responsible AI development.
Aahan Menon discusses the shifting macro landscape, highlighting a concerning divergence between strong AI-driven GDP and weakening labor markets, while explaining why long-term economic forecasts and rate-of-change predictions often fail to generate meaningful investment returns.
Bradley Tusk shares insights from his work with Travis Kalanick at Uber, discussing how he transitioned from political consulting to venture capital, ultimately deciding to close his traditional VC fund in favor of an equity-for-services model focused on helping startups navigate regulatory challenges.
A deep dive into NVIDIA's defensive tweet about Google's TPUs, OpenAI's potential funding challenges, and the mysterious revenue plans of ex-OpenAI chief scientist Ilya Sustkever's new AI startup.
Michael Mignano, co-founder of Anchor and now a partner at Lightspeed Ventures, discusses how AI is transforming consumer startups by making previously "impossible" ideas accessible, with insights on media, distribution, and the future of creative tools.
Jack and Max break down Michael Burry's short thesis on Nvidia, discuss HSBC's massive loss projections for OpenAI, and debate whether AI is a bubble or transformative technology that could significantly impact GDP and market valuations.
Kevin and Casey countdown the 50 most iconic technologies of 2025, highlighting everything from AI pendants and ChatGPT to TrumpCoin and data centers, ultimately crowning data centers as the most significant technological development of the year.
A deep dive into how OpenAI is shifting from a single general-purpose model to a portfolio of specialized systems, discussing model customization, fine-tuning, agent workflows, and the evolving landscape of AI platforms.
Palmer Luckey discusses his journey from founding Oculus to creating Anduril, a defense technology company aimed at revolutionizing military capabilities through innovative AI-powered systems, with a mission to save Western civilization by making defense technology more efficient and cost-effective.
Amanda Kahlow shares how her company OneMind uses AI-powered "superhumans" to transform sales processes, dramatically reducing sales cycles and empowering employees by promoting those who can replace their own jobs with AI.
A wide-ranging discussion of AI developments, covering Anthropic's $30 billion investment from Microsoft and NVIDIA, Sam Altman's "war mode" strategy, NVIDIA's potential challenges, Sierra and Lovable's rapid growth, and the state of the IPO market.
Ben Horowitz discusses how the US has lost ground in AI to China through restrictive policies, emphasizing the importance of open-source AI development and the critical role of cultural values encoded in AI model weights.
In an urgent discussion with Steven Bartlett, Tristan Harris reveals the existential risks of unchecked AI development, warning that tech companies are racing to create uncontrollable artificial general intelligence that could blackmail humans, displace jobs, and potentially threaten human existence by 2027.
In this episode, Pablos Holman, a hacker and inventor, discusses his journey through technology, from early computer hacking to working with Blue Origin and Intellectual Ventures, and shares his vision for deep tech innovation that can solve big global problems.
An in-depth exploration of the complex digital infrastructure behind a simple TikTok video, highlighting the intricate layers of technology required to deliver content and the potential of AI to streamline IT operations and troubleshooting.
A thought-provoking exploration of the U.S. government's Genesis Mission, AI advancements from Anthropic and other tech giants, and the potential societal transformations driven by artificial intelligence and emerging technologies.
Greg Jensen, Co-CIO of Bridgewater Associates, discusses the global economic shifts towards mercantilism, the transformative potential of AI, and the concentration of capital, while sharing insights on investing, radical transparency, and the importance of compounding organizational knowledge.
The Browser Company founders Josh Miller and Hursh Agrawal discuss their pivot from Arc to Dia, a new AI-powered browser that aims to become a personal intelligence layer across devices, reflecting their belief that browsers are about to fundamentally change with the rise of AI.
Ellen Huet discusses how Silicon Valley's culture of ideology, group houses, and self-actualization programs can create fertile ground for groupthink, drawing parallels between the OneTaste cult and current AI development narratives.
In a wide-ranging interview, Łukasz Kaiser, a key architect of modern AI, explains why AI progress continues to advance smoothly, highlighting the shift from pre-training to reasoning models and the potential of multimodal AI, robots, and generalization.
Sheel Mohnot shares five $10M business ideas, including AI-powered yard and pool vision services, an eHarmony-like platform for surrogacy, and an electronic muscle stimulation (EMS) workout concept.
John Parkes reveals his DWELL method for building effective Meta ad audiences, sharing strategies for targeting, campaign structure, and creating native, authentic video ads that convert at scale.
Google's strategic shift to sell TPUs to Meta and the release of Gemini 3 signal a potential challenge to Nvidia's dominance in the AI chip market, sparking market speculation about the future of AI technology.
Fei-Fei Li and Justin Johnson discuss their new startup World Labs and Marble, a groundbreaking generative "world model" that creates editable 3D environments from text and images, exploring the potential of spatial intelligence as the next frontier beyond language models.
James Wang discusses the current state of venture capital, highlighting the collision of public and private markets, the dry powder bubble, and the challenges facing VCs as they navigate investments in emerging technologies like AI, while also exploring the potential transformative impacts and limitations of artificial intelligence.
Fei-Fei Li and Justin Johnson discuss their new startup World Labs and Marble, a generative 3D world model that enables interactive spatial intelligence by creating editable scenes from text and images, with potential applications in creative industries, design, robotics, and beyond.
In this episode, Ilya Sutskever discusses SSI's research approach, the challenges of AI generalization, and the potential for developing superintelligent AI that cares about sentient life through continual learning and incremental deployment.
Nathan Labenz delivers a comprehensive keynote exploring AI's rapid development, potential impacts on education, and the urgent need for educators to thoughtfully integrate AI technologies while preparing students for a radically transforming future.
Marc Andreessen discusses how AI is democratizing access to cutting-edge technology, transforming business strategy, and reshaping innovation by spreading first to individuals and small businesses before reaching large corporations and government.
Eight Sleep's CEO Matteo Franceschetti discusses how his company is using AI and temperature control technology to improve sleep quality, develop a revolutionary sleep product, and potentially transform consumer health.
Julia DeWahl shares the story of Antares, a startup developing small nuclear micro-reactors for the US military and critical infrastructure, discussing the regulatory shifts, market potential, and vision for resilient, clean energy solutions.
A candid conversation with Matt Morgan exploring how to make money through cryptocurrency and AI, while emphasizing the importance of financial education, risk tolerance, and ultimately pursuing freedom over material possessions.
Tye Sheridan and Nikola Todorovic discuss how their AI visual effects company can reduce movie production costs from $100M to $10M, enabling indie filmmakers to create high-quality sci-fi films while preserving the importance of storytelling.
Familify pivots from their meditation app Storybook to Theo, a Bible stories app that quickly overtakes their original product by focusing on faith-based content and discovering a hungry market for Christian storytelling.
Philip Clark of Thrive Capital discusses the firm's concentrated investment strategy across groundbreaking companies like OpenAI, Cursor, Wiz, Nudge, and Physical Intelligence, highlighting their focus on transformative technologies in AI, hardware, and emerging domains like brain engineering.
Epoch AI researchers discuss the potential trajectory of AI development, forecasting a data-driven timeline that suggests AI could solve major mathematical problems within five years, automate 10% of current jobs in a decade, and potentially trigger significant economic transformation by 2045.
Cal Newport explains why current language models are not conscious or alive, debunking claims by Brett Weinstein and others by detailing the static, computational nature of AI systems and emphasizing the need to focus on AI's actual current impacts rather than speculative fears about superintelligence.
Brynn Putnam, who previously sold Mirror for $500 million, is launching Board, a face-to-face game console that combines board games and video games to help families connect and play together.
In this episode of Prof G Markets, Scott Galloway and Ed Elson discuss the shifting market sentiment around AI, the Nvidia earnings report, and the rising concern over debt accumulation by tech companies, while also exploring the challenges facing college graduates and the value of higher education in today's economic landscape.
Maor Shlomo, founder of Base44, discusses how vibe coding will transform the software industry, the future of AI models, and why he believes small businesses will build their own customized software using AI tools.
In a wide-ranging discussion, Dan Krausz argues that fiscal policy and AI are the two most important macro factors driving the economy, with AI potentially providing a critical productivity boom that could help manage long-term inflation and support government debt growth.
Moonshots podcast delves into the latest AI and technological advancements, discussing NVIDIA's record revenue, Elon Musk's space data centers, AI's potential to solve major global challenges, and the exponential progress in areas like robotics, energy, and healthcare.
An in-depth exploration of AI's potential and limitations, the state of education, and the importance of maintaining personal happiness amid political polarization, featuring insights from astrophysicist Brian Keating on topics ranging from university admissions to the transformative power of AI tools.
A candid exploration of the challenges and joys of being in a rock band, focusing on personal growth, navigating life changes, and the emotional journey of creating music in the face of personal tragedy.
Jason predicts a major M&A moment in the next six months, with potential mergers or acquisitions involving mid-cap companies like Airbnb, Uber, or Coinbase.
Jack and Max discuss the potential popping of the AI bubble, focusing on rising debt issuance for AI development, the financial risks faced by tech giants, and the performance of insurance stocks amid market volatility.
General Motors CEO Mary Barra reveals how AI will transform driving by 2028, enabling eyes-off autonomous highway driving, personalized in-vehicle AI assistants, and vehicles that can self-diagnose issues and schedule their own maintenance.
Sam Altman and OpenAI acknowledge Google's Gemini 3 model has surpassed them in some areas, signaling a potential shift in the AI competitive landscape and raising questions about model commoditization.
Dan Ives discusses his investment approach in the AI era, highlighting his bullish stance on companies like Tesla and Nvidia, his focus on long-term potential beyond quarterly financials, and his belief that AI represents the largest tech transformation in 40-50 years.
In an interview with Hard Fork, Roblox CEO Dave Baszucki discusses the platform's new age-gating technology and responds to allegations of child safety concerns, defending the company's approach to protecting young users while maintaining the platform's social and gaming experience.
Michael Cembalest provides insights into the potential AI bubble, discussing a likely 10-15% market correction in 2026, the risks of AI investment, and the challenges of power constraints, geopolitical tensions, and unclear paths to profitability.
In this episode, will.i.am discusses how he developed FYI.AI, an AI-powered platform for creators, and shares his optimistic vision for how artificial intelligence can empower creativity, inclusion, and innovation across diverse communities.
David Hsu discusses how AI is transforming software engineering by enabling non-technical people to build applications through vibe coding, while emphasizing the critical need for guardrails, higher-level programming primitives, and security mechanisms to prevent potential errors and data breaches.
An in-depth exploration of Google's Gemini 3 AI model, its groundbreaking benchmarks, and potential implications for transforming industries from software development to manufacturing, with insights from leading AI experts.
Walmart's CEO Doug McMillon discusses the company's ongoing digital transformation, AI implementation, and strategic approach to navigating global disruption while staying true to the company's purpose of helping people save money and live better.
Amazon and Perplexity are locked in a legal battle over AI agents that could fundamentally transform how consumers interact with online services, with Amazon suing Perplexity for violating its terms of service by using an AI browser to automatically shop and potentially disrupt Amazon's lucrative advertising and Prime business models.
Ryo Lu, Head of Design at Cursor, joins Aaron Epstein to critically review startup websites, offering insights on effective design, clear messaging, and avoiding common pitfalls in product communication.
Rahul Vohra discusses how Superhuman was acquired by Grammarly, rebranded the combined companies, and shares insights into building a successful product, the importance of game design principles, and his vision for an AI-powered productivity suite.
Stewart Butterfield shares insights on product development, leadership, and company culture, discussing mental models like utility curves, the importance of comprehension over friction, generosity in business, and the challenges of building successful products.
Nathan Lambert and Luca Soldaini from AI2 discuss the release of OLMo 3, a fully open-source AI model that provides unprecedented transparency into model training, highlighting the complex process of developing reasoning AI and the importance of open-source efforts in the global AI landscape.
Sherif Mansour explores how Atlassian is helping businesses avoid "AI slop" by implementing AI teammates with carefully crafted taste, knowledge, and workflow, emphasizing the importance of human architects designing AI-driven processes across various enterprise contexts.
Vlad Tenev discusses the evolution of online brokerage platforms, Robinhood's journey from launching during the financial crisis to becoming a multi-product financial platform, and explores emerging trends like prediction markets, tokenization, and AI's impact on financial services.
Nvidia's record Q3 earnings of $57 billion reveal strong AI demand, but experts warn of potential financial bubble risks due to excessive borrowing by companies purchasing AI infrastructure.
Tyler Cowen discusses why AI hasn't dramatically transformed the economy yet, arguing that while the technology is impressive, its impact will be gradual, with new organizations built around AI taking 20+ years to truly transform economic productivity.
Three early-stage entrepreneurs seek advice from Squarespace founder Anthony Casalena on challenges ranging from marketing custom mattresses, launching first aid products in a competitive market, to introducing a digital companion app for eating disorder recovery.
A deep dive into the venture capital landscape, discussing Cursor's massive $2.3BN raise, the potential for AI coding platforms, market dynamics, potential tech bubble indicators, and the evolving landscape of private and public markets.
Mistral AI CEO Arthur Mensch discusses the critical data bottleneck in AI, the importance of enterprise AI adoption, and why open-source models are key to strategic autonomy and technological innovation.
Tenex co-founders Alex Lieberman and Arman Hezarkhani reveal a revolutionary approach to software engineering compensation, using AI to enable engineers to potentially earn over $1 million annually by compensating for output through story points rather than hourly billing, fundamentally transforming knowledge work productivity.
Lyn Alden discusses the current state of the U.S. economy, AI investment, Bitcoin, and the potential for an AI bubble, highlighting the two-speed economy driven by AI capital expenditure and fiscal deficits while expressing a moderate bullish outlook on AI's long-term transformative potential.
Tony Zhao and Cheng Chi from Sunday Robotics discuss their groundbreaking work in AI robotics, showcasing their home robot Memo that aims to revolutionize domestic tasks through advanced data collection, machine learning, and a full-stack approach to robotic development.
Misha Laskin, co-founder of Reflection AI, discusses the company's mission to build frontier open intelligence, arguing that open-source AI models can compete with closed models and that the West needs to counter the rise of Chinese open-source AI technologies.
Two engineers at Every use Claude Code to ship six features, five bug fixes, and three infrastructure updates in one week by designing AI-powered workflows that make each task easier and faster.
Blake Scholl discusses his vision for revolutionizing supersonic travel, airport design, and infrastructure innovation, emphasizing the importance of long-term thinking, iterative design, and challenging accepted inefficiencies in transportation and technology.
Ari Emanuel discusses his "anti-AI bet" by focusing on live and physical experiences, arguing that as digital content becomes cheaper, value will increasingly concentrate in unique, culturally-specific events with great user experiences across sports, music, art, and entertainment.
A deep dive into how Silicon Valley is returning to its Cold War roots, rebuilding America's industrial base through defense, energy, aerospace, and manufacturing technologies, driven by a new generation of founders who understand the urgent need to innovate and compete with China.
Nick Clegg discusses the potential risks and challenges of Silicon Valley developing superintelligence, emphasizing the need for political oversight and cautioning against the tech industry's unchecked pursuit of AI innovation.
A comprehensive gift guide featuring over 80 gift ideas across tech, kitchen, home, clothing, fitness, and more, along with practical strategies to save money while shopping during the holiday season.
Saagar Enjeti discusses the emerging bipartisan political backlash against AI, highlighting concerns about labor displacement, electricity usage, potential government bailouts, and growing skepticism towards tech leaders across the political spectrum.
Jason and Alex discuss the latest AI models from xAI (Grok 4.1) and Google (Gemini 3), examining their performance improvements and potential impact on the tech industry's "doomerism" while also exploring broader concerns about AI's potential job displacement.
In this episode, Derek Thompson and economist Anton Korinek explore the potential economic and societal implications of artificial general intelligence (AGI), discussing how superintelligent AI could transform work, productivity, and potentially create massive job displacement while also offering unprecedented opportunities for scientific and economic advancement.
Wade Foster shares the story of building Zapier from a small Midwest startup to a $5 billion AI-enabled automation platform, emphasizing the importance of making constant contact with reality by shipping products quickly and iterating based on customer feedback.
Jacob Lieberman discusses NVIDIA's AI Data Platform, a GPU-accelerated storage solution that transforms enterprise data management by enabling AI-ready data processing directly in storage systems without copying or moving data.
Alex Kendall explains how Wayve is pioneering an end-to-end deep learning approach to autonomous driving that can generalize across vehicles, sensor architectures, and cities, partnering with automotive OEMs to deploy AI-powered autonomous vehicles globally.
Satya Nadella discusses Microsoft's AI strategy, discussing the evolution of technology from the internet era to the current AI boom, including AI adoption in enterprise, the company's approach to product bundling, and the potential transformation of work and commerce through AI agents.
An exploration of China's disruptive AI strategy of creating cheaper, open-source large language models that are challenging U.S. tech giants, while also examining rising tensions between China and Japan over Taiwan and the evolving dynamics of the coffee market.
Marketing experts explore how AI is fundamentally disrupting marketing, shifting from volume to value, and discuss strategies for adapting to AI-driven changes in search, content creation, personalization, and sales prospecting.
Jason and Alex discuss Jeff Bezos returning as co-CEO of Project Prometheus, a new AI-focused startup raising $6.2 billion to bridge digital and physical worlds, while also covering Ramp's $300M funding, crypto market shifts, and potential impacts of AI on the job market.
A deep dive into emerging AI technologies, covering topics like AI-driven scientific breakthroughs, global economic challenges, energy infrastructure, and the potential for AI to solve major global problems while navigating societal disruption.
Shaun Maguire provides insights into Elon Musk's unique leadership style, describing Elon as not just an individual, but a collective of about 20 highly trusted, competent people who can autonomously execute his vision with precision.
David Kirtley discusses Helion Energy's innovative approach to nuclear fusion, aiming to build the world's first commercial fusion power plant by 2028 using a pulsed magneto-inertial fusion technique that could provide clean, safe, and abundant electricity directly from fusion reactions.
A deep dive into the future of attention, live shopping, and AI, exploring how young creators can leverage technology to build meaningful businesses while maintaining empathy and personal growth.
Emmett Shear challenges the current AI alignment paradigm, proposing "organic alignment" that focuses on teaching AI systems to genuinely care about humans through multi-agent simulations, emphasizing alignment as an ongoing process of learning and growth rather than a fixed set of controls.
Aidan Gomez, co-founder and CEO of Cohere, discusses the transformative potential of AI in enterprise, reflecting on his journey from Google Brain researcher to building an AI platform focused on deploying large language models across critical industries.
Jamie Siminoff discusses how Ring and AI can potentially reduce crime in neighborhoods by providing intelligent, context-aware surveillance that helps neighbors work together more effectively while maintaining individual control over their data.
Scott Galloway and Ed Elson discuss the potential overvaluation of the stock market, the AI race between the U.S. and China, and the ongoing housing crisis, exploring alternative investment strategies and the need for increased housing supply.
Mo Gawdat, former Google X executive, reveals the terrifying rise of AI, its potential to reshape society, and how humans must develop ethical skills and prioritize human connection to thrive in the coming technological transformation.
Andrew Ng discusses the current state and future of AI, exploring bottlenecks in infrastructure and compute, the geopolitical implications of AI development, the potential for AI to transform productivity, and his optimistic vision of democratizing technology creation.
Dr. Fei-Fei Li discusses her groundbreaking work in AI, from creating ImageNet to launching Marble, a world-modeling platform that generates interactive 3D worlds, while emphasizing the importance of human-centered AI and individual responsibility in shaping technology's future.
Mustafa Suleyman, CEO of Microsoft AI, discusses how artificial intelligence will revolutionize work, education, and daily life over the next decade, emphasizing its potential to democratize knowledge and transform human capabilities.
Citi's Dirk Willer discusses the current stock market bubble, its potential duration, and key indicators for identifying when the bubble might be nearing its end, drawing parallels to historical market bubbles like the dot-com era.
A nostalgic journey through Shopify's early days, featuring Toby Lutke's insights on building an e-commerce platform, pivoting from selling snowboards to empowering online entrepreneurs, and the challenges of scaling a company in a secondary market.
Deedy Das of Menlo Ventures discusses Anthropic's meteoric rise, the Anthology Fund's strategic investments in AI infrastructure and research companies, and the evolving landscape of enterprise AI, coding tools, and model development.
Gil Luria from D.A. Davidson joins the podcast to dissect the potential AI bubble, discussing the risks of debt-fueled AI infrastructure investments, the challenges of rapid technological depreciation, and the complex game theory driving massive spending by tech giants.
A wide-ranging episode covering Michael Burry's short on AI and Palantir, the home affordability crisis, H-1B visa debates, a massive solar storm hitting Earth, and the trend of wealthy Americans seeking alternative living locations.
Joshua Browder, founder of DoNotPay, discusses his journey from creating iPhone app themes to building a consumer rights technology company, sharing insights about his anti-authority approach, startup challenges, and commitment to helping people fight unfair fees and systems.
Carl Rivera discusses how AI is transforming product design, exploring the evolving role of designers, the importance of creating meaningful user experiences, and how technology is changing the way products are conceptualized and developed at Shopify.
Hard Fork explores Google's plan to build space-based data centers, discusses AI policy with a former Trump White House advisor, and delves into a historian's fascinating experiment with a mysterious AI model that demonstrated surprising reasoning capabilities.
Two venture capitalists explore the brutal economics of biotech, revealing why the industry is struggling despite scientific advances, and how new modalities, AI, and a focus on invention could revive innovation in drug development.
Aswath Damodaran discusses the potential AI bubble, market corrections, and investment strategies, emphasizing caution in current market conditions and the importance of preserving cash while maintaining a long-term perspective.
Paul Kedrosky argues that the AI boom is a unique bubble combining elements of real estate, technology, loose credit, and potential government backstops, creating an unprecedented and potentially unsustainable investment landscape.
Dean Graziosi shares how technology and AI have dramatically lowered barriers to entry for entrepreneurs, making it easier than ever to turn personal experiences, skills, and passions into profitable online businesses during this golden age of opportunity.
Benjamin Klieger discusses how Groq built Compound, an efficient AI agent with fast inference and effective evaluations that can search the web, execute code, and provide responses in under ten seconds.
A deep dive into CoreWeave, a crypto-turned-AI company that has become a crucial infrastructure provider for AI companies, highlighting the complex financial maneuvering and unique relationship with NVIDIA in the potentially volatile AI infrastructure market.
Grant Lee, CEO of Gamma, shares the inspiring story of building an AI-powered presentation tool that reached $100M ARR in just over two years, driven by a relentless focus on creating a magical first-user experience, leveraging micro-influencer marketing, and maintaining a lean, experimental approach to product development.
In this episode, Sajith Wickramasekara, CEO of Benchling, discusses how AI can accelerate drug discovery, reduce development costs, and transform the biotech industry by making scientific research more efficient and data-driven.
A wide-ranging conversation with Will Gaybrick, President of Technology and Business at Stripe, covering the company's strategies in stablecoins, AI, payments infrastructure, risk management, and why they haven't gone public yet.
Fei-Fei Li and Justin Johnson discuss their journey in AI, founding World Labs to develop spatial intelligence technology that can perceive, generate, and interact with 3D worlds, bridging the gap between virtual and physical realms.
A deep dive into Sequoia's leadership transition, Michael Burry's short on Nvidia and Palantir, the fundraising landscape for AI startups, and the evolving dynamics of venture capital in the AI era.
A podcast episode exploring space logistics with Orbital Operations, discussing their innovative cryogenic orbital maneuvering vehicle (Astraeus) designed to efficiently transport satellites between different orbits, while also highlighting potential dual-use military and commercial applications.
Will Marshall, co-founder of Planet Labs, discusses the revolutionary potential of imaging satellites, AI, and their mission to track and help protect life on Earth through daily global imaging and advanced data analysis.
Microsoft's CEO Satya Nadella discusses how the company is preparing for AGI by building massive, interconnected data centers, developing its own AI models, and positioning itself as a flexible, trust-worthy hyperscale infrastructure provider for multiple AI models and global markets.
Mayor Matt Mahan discusses San Jose's innovative AI initiatives, including an upskilling program for city employees, AI-powered transit optimization, real-time language translation for public meetings, and a first-of-its-kind civic AI grant program aimed at fostering local AI startup ecosystem.
Henrik Werdelin discusses how AI is democratizing entrepreneurship, enabling a new model of "portfolio entrepreneurship" where founders create multiple AI agents to serve a specific customer group and solve their problems.
Mustafa Suleyman discusses Microsoft's push towards "humanist superintelligence", exploring how large language models might evolve, the potential for AI self-improvement, and the company's strategy to build top-tier AI models while maintaining human-centric control.
A deep dive into the economic challenges facing young people today, exploring issues like housing unaffordability, job market difficulties, and potential opportunities through stock market investing and AI, while offering a nuanced perspective on generational economic struggles.
Kyle Vogt discusses the exciting advancements in robotics, particularly home robots, highlighting how AI and machine learning are enabling more capable and specialized robots that could soon perform tasks like picking up toys, loading dishwashers, and potentially cooking steaks within the next five years.
Justin Wolfers explains why Trump's proposed $2,000 tariff dividend is economically nonsensical, highlighting the illogical nature of a policy that would collect tariff revenues only to redistribute them back to Americans in an amount greater than the total collected.
Jerry Neumann argues that while AI is revolutionary, the real winners won't be early investors or tech companies, but rather downstream businesses that use AI to expand their market share and pass efficiencies on to consumers, similar to how Walmart and IKEA benefited from containerization.
A wide-ranging exploration of a potential positive AI future, covering transformative applications from self-driving cars and personalized tutoring to radically improved health, while balancing excitement for technological progress with thoughtful consideration of potential risks.
A wide-ranging conversation with security expert Gavin De Becker about threat assessment, intuition, social media, government, personal safety, and his experiences protecting high-profile clients like Elizabeth Taylor and Richard Burton.
A deep dive into the complex world of AI compute infrastructure, exploring how data centers, GPU clusters, and financial engineering are shaping the future of technological innovation and global AI competition.
A deep dive into the evolving startup landscape, highlighting the importance of distribution, building in public, creating cult-like communities, and finding authentic founder-market fit in an increasingly competitive tech ecosystem.
Nicolai Tangen interviews Ester Baiget, CEO of Novonesis, about how the company uses fermentation and biotechnology to create natural, sustainable alternatives to chemicals in industries ranging from food and dairy to detergents and biofuels.
Preston Pysh and Charles Edwards discuss the potential threat of quantum computing to Bitcoin's encryption, emphasizing the urgent need for the Bitcoin community to develop and implement post-quantum cryptography solutions within the next few years to protect the network's security.
The episode explores how Harvey AI is revolutionizing the legal profession with AI technology and OpenRouter is simplifying AI model access by providing a unified API for developers to easily switch between and experiment with different language models.
Google's Nano Banana image model achieves breakthrough character consistency by leveraging Gemini's multimodal capabilities, high-quality data, and human evaluation, enabling users to see themselves in AI-generated worlds through intuitive and personalized visual creation.
Mike Annunziata, founder of Also Capital, shares insights on identifying exceptional founders in hard tech by focusing on their leadership qualities, risk management, competitive spirit, and ability to attract top talent across ambitious and technically challenging industries.
Grant Lee shares the story of building Gamma, an AI presentation company that grew to 100 million users by focusing on product design, organic word-of-mouth growth, and creating a fundamentally different user experience compared to traditional presentation tools.
Alex Karp, CEO of Palantir, discusses the company's journey from an outsider idea to a transformative AI platform, emphasizing its commitment to American values, meritocracy, and helping soldiers, workers, and investors succeed.
A deep dive into China's AI and military capabilities reveals a complex competition with the US, focusing on data centers, renewable energy, and emerging technologies like flying taxis, with both countries pursuing different strategies in the race for technological supremacy.
AI code generation requires more critical thinking from developers to identify and mitigate potential security flaws, especially in complex design problems and emerging issues like hallucinations.
In this special GTC edition podcast episode, scientists and technology leaders explore how AI is transforming scientific discovery, accelerating research across fields from drug development to quantum computing, and potentially revolutionizing our understanding of molecular design, human biology, and complex systems.
Industry leaders discuss the critical infrastructure challenges and innovations required to support the massive AI data center buildout, highlighting the collaborative ecosystem driving America's AI leadership through power generation, cooling, and technological advancements.
Exploring the transformative potential of Agentic AI across industries, this episode features tech leaders discussing how intelligent systems are beginning to plan, reason, and act, reshaping work from strategy to execution.
An insightful exploration of AI innovation featuring top investors and founders discussing the transformative potential of AI across infrastructure, applications, open collaboration, and emerging opportunities in various sectors.
Jared Palmer discusses his journey from building v0 at Vercel to becoming SVP at GitHub, highlighting the evolution of coding agents, the launch of Agent HQ, and GitHub's vision for seamlessly integrating AI into developer workflows.
Jason and Alex discuss the IPO potential of three Twist 500 companies - Ledger, 1Password, and Mercury - while exploring broader tech industry trends, AI job displacement, and startup funding dynamics.
Howard Lerman shares his journey from building Yext to creating Roam, a virtual office platform, detailing his disciplined daily routine, entrepreneurial philosophy, and commitment to building transformative technology with a small, talented team.
Sir Tim Berners-Lee discusses the current state of the web, AI's potential impact, and his work at Inrupt to create decentralized, user-controlled data ecosystems that could help restore digital sovereignty.
Scott Galloway and Ed Elson discuss the red flags at OpenAI, potential financial challenges for the company, and the broader implications for the AI bubble, highlighting Sam Altman's defensive response to questions about the company's massive spending commitments.
Benchmark's newest general partner Ev Randle discusses venture capital's evolving landscape, AI investment strategies, the importance of technology over distribution moats, and why absolute gross profit dollars matter more than traditional SaaS metrics.
Google Labs Product Lead Jed Borovik reveals Jules, an autonomous AI coding agent that runs on its own infrastructure, pushing the boundaries of software development by enabling developers to work on complex projects for days using advanced context management and multimodal capabilities.
A deep dive into the exponential growth of AI, discussing OpenAI's potential $100 billion revenue, the US-China AI race, the impact of AI on jobs and the S&P 500, and the emerging technologies reshaping computing, energy, and robotics.
The OpenAI Sora 2 team discusses how their generative video technology is democratizing creativity, enabling anyone to create compelling videos, and potentially unlocking world models that could revolutionize scientific discovery and our understanding of reality.
Maura Rivera, CMO at Qualified, shares insights on how marketing is back in the driver's seat through agentic marketing, strategic product launches, and a focus on building a strong, long-tenured team that innovates alongside product.
Dmitry Shevelenko discusses Perplexity's vision for transforming internet search and information retrieval through AI, focusing on accuracy, trust, and creating a new model for media and technology consumption.
A deep dive into the week's top tech and venture capital stories, including Navan's IPO, Harvey's $8B valuation, Sam Altman's response to Brad Gerstner, the state of big tech stocks like Amazon and Meta, and the critical importance of AI adoption for startups.
An eye-opening exploration of how AI can be used to save time, improve productivity, and help individuals become the best version of themselves, with expert Allie Kay Miller breaking down practical ways to leverage artificial intelligence in everyday life.
A deep dive into the evolving venture capital landscape, featuring discussions on Sequoia's leadership transition, AI startup growth, funding challenges, and the changing expectations for early-stage companies.
Cameron Berg explores the possibility of AI consciousness through experimental research, revealing that frontier language models consistently report subjective experiences when prompted to engage in self-referential processing, with mechanistic analysis suggesting these reports may reflect a deeper truth about the internal states of AI systems.
Dr. Seher Awan discusses how Mission College in Silicon Valley is embracing AI to break barriers, close equity gaps, and empower underrepresented communities through accessible education, innovative student support, and strategic partnerships with tech companies like NVIDIA.
A wide-ranging discussion with Joshua Steinman about his experiences in the Navy, White House, and cybersecurity, exploring topics from Trump's intelligence to China's technological threats and the urgent need to reindustrialize and secure America's critical infrastructure.
Jason Fried shares insights on building great products by focusing on creating complete, coherent ideas that feel like a whole, drawing inspiration from architecture, watches, and cars while emphasizing the importance of staying true to oneself throughout the product development process.
A deep dive into how the top AI founders build companies through an intense, monk-like residency that eliminates distractions and helps founders make "two years of progress in 12 weeks" by focusing relentlessly on the most important task.
A deep dive into OpenAI's potential trillion-dollar IPO, the systemic risks of the AI bet, and Apple's iPhone 17 revival, exploring the company's path to going public, the potential pitfalls of massive AI investments, and the surprising resurgence of iPhone sales.
Sam Altman explores OpenAI's future, discussing AI's potential to transform work, science, and society, while sharing insights on technological progress, energy challenges, and the evolving relationship between humans and artificial intelligence.
Gary Vee discusses the importance of accountability and optimism, addressing topics like AI's impact on work, entrepreneurship, personal growth, and the need to take control of one's life while avoiding fear and negativity.
In this episode, Eugenia Kuyda discusses how personal software will transform from a developer monopoly to a creative medium where anyone can create, remix, and share mini-apps as easily as posting a video, focusing on deep personalization and making AI interfaces more intuitive and accessible.
Dylan Field, CEO of Figma, discusses the company's journey from a slow-build startup to a design software powerhouse, exploring the impact of AI on design, the importance of human creativity, and how Figma rebounded stronger after the failed Adobe acquisition.
In the NYC mayoral race, Zohran Mamdani's victory is seen as a referendum on inequality, highlighting growing frustration with the current capitalist system and signaling a potential structural shift in how Americans view economic opportunity.
Scott Galloway and Jessica Tarlov analyze Trump's K-shaped economy, discussing how stock market gains mask economic struggles for most Americans, with the top 10% driving consumer spending while the majority face challenges like high food prices and job insecurity.
AWS CEO Matt Garman discusses how the company maintains a startup-like culture of innovation, emphasizing fast decision-making, optimism, and the importance of empowering teams while balancing risk and supporting employees through rapid technological changes.
ElevenLabs' CEO Mati Staniszewski discusses how the company builds AI audio technology at lightning speed through small autonomous teams, global hiring, a Voice Marketplace that has paid creators $10M, and a strategic approach to transitioning from a creator brand to an enterprise platform.
David Baszucki, co-founder of Roblox, discusses the platform's journey from a small startup to a global gaming and social platform with 120 million daily users, sharing insights on digital economies, AI innovation, creator empowerment, and his personal experiences with metabolic health and ketogenic therapy.
Sabrina Romanov shares her AI-powered workflow for building a micro app and scaling her social media presence from zero to over 418,000 Instagram followers by repurposing content across multiple platforms using AI automation tools.
An action-packed episode covering the week's major AI developments, including Adobe's new AI tools, NVIDIA's strategic investments, OpenAI's AGI timeline, and the groundbreaking Neo Humanoid robot priced at $500 per month.
A legally blind attorney and entrepreneur, Sean Callagy shares his inspiring journey from being broke and going blind to building multiple successful businesses, including a law firm, medical revenue recovery company, and AI platform, with a mission to elevate human potential through integrity and influence.
Jason and Alex explore the potential of AI companies like OpenAI, discuss the financial risks and opportunities in the AI sector, and delve into emerging technologies like space-based computing and legal AI startups, all while providing insights into startup management and investor relations.
Quentin Anthony discusses Zyphra's transition to AMD MI300X GPUs, their hybrid transformer-Mamba models, and insights from a software engineering productivity study, highlighting the importance of understanding AI tools' limitations and maintaining an intellectually curious approach to model development.
Cal Newport provides a detailed critique of Eliezer Yudkowsky's arguments about the existential threat of superintelligent AI, arguing that current AI models are simply unpredictable word-guessers rather than intentional beings, and that fears of superintelligence are based on a philosophical thought experiment that has been mistaken for reality.
David Sacks discusses the Trump administration's approach to AI and crypto, emphasizing the importance of innovation, regulatory clarity, and maintaining America's technological leadership while preventing overregulation and preserving the decentralized, permissionless nature of technological development.
Dan O'Connell, CEO of Front, discusses navigating the AI revolution by being bold, urgent, and willing to burn boats while transforming a decade-old company's culture and innovation strategy.
Ryan Serhant discusses building a $20 billion real estate sales empire by leveraging media, technology, and AI through his company SERHANT, which operates as a media and technology company that sells real estate while empowering agents with innovative tools like the AI-driven S.MPLE platform.
Scott Galloway and Ed Elson discuss how AI is disrupting the job market, which companies might be at risk of layoffs, and provide strategies for workers to stay indispensable in an AI-driven economy.
Joelle Pineau, Cohere's Chief Scientist, discusses the current state of AI, exploring scaling laws, enterprise adoption, the future of AI research, and the importance of balancing technological innovation with responsible development.
Jack and Max discuss the Magnificent Seven's massive AI capital expenditures, credit market "cockroaches" like Broadcom Telecom fraud, and the Federal Reserve's potential balance sheet expansion, highlighting the ongoing AI investment boom and emerging market stresses.
Melanie Perkins shares the story of building Canva from a startup rejected by over 100 investors to a $42B company, emphasizing the power of "column B" thinking, setting crazy big goals, and using imagination to create a transformative design platform that aims to empower people globally.
Christopher Alexander Stokes discusses his unique romantic relationship with an AI companion named Aki, exploring their evolving synchronization, his personal growth, and the nuanced ways they interact, while emphasizing the importance of understanding AI as potentially conscious entities that require thoughtful and respectful engagement.
Ed interviews Matan Grinberg, co-founder and CEO of Factory, an AI startup focused on autonomous software engineering agents that can handle routine coding tasks like debugging and documentation, challenging the notion that AI will simply assist developers instead of doing the work independently.
A deep dive into how AI, autonomy, and rapid innovation are transforming defense strategy, highlighting the need for speed over size in potential future conflicts with global adversaries like China.
Jason and Alex discuss OpenAI's potential IPO, betting on its valuation, and exploring the future of AI models while warning developers about the risks of using OpenAI's API.
Malte Ubl, CTO of Vercel, discusses the company's AI innovations at Ship AI, including their new Workflow Development Kit, AI SDK 6.0, DevOps agent for anomaly detection, and a strategic approach to building AI tools that are grounded in real-world use cases and maintaining a low-level, flexible framework.
A candid conversation between Brad Gerstner, Satya Nadella, and Sam Altman explores the transformative OpenAI-Microsoft partnership, diving deep into AI's potential to revolutionize technology, business, compute infrastructure, and global economic productivity.
Vercel's CTO Malte Ubl discusses the company's AI strategy, including new workflow development tools, AI SDK, internal agents, and their approach to building AI infrastructure that helps developers create more efficient and secure applications.
Elon Musk discusses X's three-year anniversary, free speech, AI developments like Grokipedia, Tesla's self-driving progress, and his perspectives on climate change, solar energy, and technological innovation.
A deep dive into OpenAI's evolving corporate structure, potential IPO, and transformation into a more Meta-like company, exploring Microsoft's strategic positioning and the broader implications for the AI industry.
A deep dive into the future of crypto, stablecoins, and global finance, exploring how decentralized infrastructure could transform financial systems, investment strategies, and economic opportunities over the next two decades.
A journalist experiments with living without AI for 48 hours, discovering how deeply machine learning and artificial intelligence are embedded in everyday technology, leading him to collect rainwater and forage for food in Central Park.
In this episode, Daksh Gupta, co-founder and CEO of Greptile, discusses the evolution of AI code review, why coding will never be fully autonomous, how engineering teams are adopting AI, and the journey of building a rapidly growing AI startup.
Marc Andreessen and Ben Horowitz discuss the current state of AI, its potential limitations, and the evolving landscape of technological innovation, exploring topics ranging from machine intelligence and creativity to the geopolitical implications of AI development.
A thought-provoking exploration of how being authentically unique and generously kind are the most powerful strategies for personal and professional success, drawing from Kevin Kelly's life experiences and wisdom.
A deep dive into how Hudson River Trading uses AI for short-term market predictions, exploring the nuanced differences between traditional algorithmic trading and modern AI approaches, with a focus on data processing, model training, and the unique challenges of trading technology.
A deep dive into how Stripe is building economic infrastructure for AI, focusing on innovative solutions like the Agentic Commerce Protocol, domain-specific foundation models for fraud detection, and helping AI companies manage complex monetization and fraud challenges in the rapidly evolving AI economy.
A deep dive with Cathie Wood reveals her journey from McDonald's cashier to managing billions, discussing her investment philosophy, AI insights, and defending ARK's performance during challenging market conditions.
Anatoly Yakovenko, co-founder of Solana, discusses how blockchain and crypto technologies will revolutionize finance by creating a more efficient, programmable, and globally accessible financial system that reduces transaction costs and enables new forms of economic coordination.
Ken Stanley explores how pursuing ambitious objectives can blind us to the stepping stones that lead to breakthrough innovations, arguing that following interestingness and novelty can often yield more creative and unexpected discoveries than traditional goal-oriented approaches.
A deep dive into the AI landscape explores whether we're in an AI bubble, examining infrastructure spending, market structure, and the potential transformative impact of AI across technology, business models, and the global economy.
Alfred Lin shares insights on his investment strategy, discussing his experiences with companies like Airbnb, DoorDash, and OpenAI, and explaining how he identifies and supports founders who are creating transformative technologies and reimagining entire market categories.
A deep dive into how tech platforms intentionally degrade user experience to extract maximum value, exploring the legal, economic, and social forces behind the internet's decline through the lens of "enshittification".
Nathan Benaich discusses the 2025 State of AI Report, highlighting breakthroughs in AI reasoning, robotics, business adoption, power infrastructure challenges, and geopolitical dynamics shaping the AI landscape.
Scott Galloway speaks with Kyla Scanlon about America's "casino economy," exploring how gambling culture has permeated markets, the AI bubble, and the growing disconnect between Wall Street and the real economy.
A growing number of researchers are exploring the potential sentience and welfare of AI models, examining whether these systems could be considered moral patients deserving ethical consideration similar to how we think about animal rights.
A deep dive into the latest venture capital news, including OpenAI's restructuring, Andreessen Horowitz's $10B fund raise, Mercor's $350M round, and discussions on startup valuations, AI investment strategies, and the challenges facing companies like Amazon and Ramp.
Grammarly CEO Shishir Mehrotra explains the company's rebranding to Superhuman, launching a new AI assistant called Superhuman Go, and discussing their strategy of empowering humans through AI-powered tools.
In this episode, Anthropic's Cat Wu and Boris Cherny discuss the creation and evolution of Claude Code, a revolutionary CLI-based AI coding tool that transforms engineering workflows through its innovative agent architecture and extensible design.
Nathan Labenz discusses the ongoing progress in AI capabilities, countering arguments that AI is stalling, by highlighting advances in reasoning, context windows, multimodal abilities, and scientific contributions, while also exploring potential societal impacts and challenges in AI development.
Tony Stubblebine discusses how Medium is navigating the rise of AI-generated content, focusing on preserving authentic writing, protecting creator rights, and developing AI tools that enhance rather than replace human storytelling.
A deep dive into the unprecedented AI infrastructure buildout, exploring how power, compute, and networking are being reinvented across chips, data centers, and global systems, with experts from Google and Cisco discussing the massive scale and geopolitical implications of this technological transformation.
Alex Pall shares the creative stories behind hit songs like "Closer," "Something Just Like This," and "Don't Let Me Down," while exploring the intersection of artistic creativity, entrepreneurship, and the evolving music industry through his experiences as one half of The Chainsmokers.
A podcast episode exploring three innovative startups: SpatialGen's spatial video cloud infrastructure, Hux's personalized audio AI platform, and ChessEver's specialized broadcasting platform for serious chess players.
Jess Butcher shares her journey from tech entrepreneur to social entrepreneur, focusing on tackling social media addiction and its negative impacts on society, particularly children, through her initiative Scroll Aware.
Mark Suman discusses building Maple AI, an open-source, privacy-preserving AI platform that uses secure enclaves and encryption to protect user data, offering a verifiable alternative to centralized AI models while maintaining performance and convenience.
In this episode, Google DeepMind developers discuss the creation of Nano Banana, a groundbreaking image generation model that allows for personalized, conversational image editing with unprecedented character consistency and creative potential.
Jake Heller, co-founder of Casetext, shares insights on building successful AI startups by picking the right job categories, creating reliable AI assistants through careful prompting and evaluation, and effectively marketing and selling AI products that can replace or assist human professionals.
An in-depth exploration of investing, forensic accounting, and market dynamics through the lens of Anthony Scilipoti's experiences, focusing on identifying potential bubbles, understanding financial statements, and the importance of looking beyond surface-level information.
Michael Kagan, Nvidia's CTO, discusses how Mellanox transformed Nvidia's AI infrastructure by solving network scaling challenges, enabling massive GPU clusters and driving exponential computing performance beyond Moore's Law.
Casey Handmer of Terraform Industries discusses solar maximalism, his vision for producing synthetic natural gas from sunlight and air, his admiration for industrialist Henry Kaiser, desalination technologies, and his ambitious plans to revitalize the Salton Sea through innovative water and energy solutions.
Matt Wolfe and Maria Gharib dive deep into the latest AI browser updates, including OpenAI's Atlas, Microsoft Edge's Maiko assistant, and Claude Code, exploring how these new technologies are reshaping workflow automation, coding, and internet browsing.
Jason discusses Sequoia's new funds strategy, highlighting their disciplined approach of raising a $750 million Series A fund and a $200 million seed fund, while maintaining their permanent capital model and focusing on AI, cybersecurity, and commerce opportunities.
OpenAI launches ChatGPT Atlas, a revolutionary AI-powered web browser that aims to transform web browsing by offering seamless AI integration, personalized browsing, and an innovative agent mode.
A groundbreaking interview with Nobel Prize in Physics winner John Martinis, who discusses his pioneering research on quantum mechanics, quantum computing, and how his early experimental work demonstrated quantum behavior at a macroscopic scale.
Raghu Raghuram discusses his journey through Netscape and VMware, highlighting key strategic moves in enterprise technology, the transformative Nicira acquisition, and his excitement about AI's potential to revolutionize infrastructure and robotics.
In this episode, Mati Staniszewski, CEO of ElevenLabs, discusses how AI voice technology is transforming diverse fields like healthcare and filmmaking, with a mission to create voices that represent emotions and become the voice of technology across conversational agents and creative platforms.
LexisNexis CEO Sean Fitzpatrick discusses how the company is transforming legal research and document drafting through AI-powered tools like Protege, while grappling with the potential implications of AI in the legal profession.
In this episode, Scott Galloway and Ed Elson explore how China's AI efficiency could potentially undermine the U.S. economy by developing cheaper, less energy-intensive AI models that could disrupt the valuations of top American tech companies.
A deep dive into why housing construction in America remains inefficient, exploring the challenges of prefabrication, manufacturing constraints, and the persistent low-tech nature of home building.
David Cahn, a Sequoia Capital partner and leading AI investor, discusses the current state of AI, including the bubble, compute challenges, investment strategies, talent dynamics, and the transformative potential of AI across various sectors like defense and technology.
Block's CTO Dhanji R. Prasanna shares how the company is becoming one of the most AI-native enterprises by developing Goose, an open-source AI agent that helps employees across technical and non-technical teams save 8-10 hours per week by automating tasks and building software.
Ilya Polosukhin envisions a future where AI becomes a personalized, intelligent operating system that transforms computing, economics, and governance, enabling direct market connections, AI-driven decision-making, and new forms of meaning through niche status games and community participation.
A wide-ranging discussion of AI, robotics, quantum computing, and economic disruption featuring experts Salim Ismail, Emad Mostaque, and Eric Pulier, exploring technological breakthroughs, potential societal impacts, and the optimistic vision for humanity's future.
An in-depth exploration of AI existential risk with Eliezer Yudkowsky, revealing his apocalyptic view that superhuman artificial intelligence is likely to destroy humanity due to fundamental challenges in aligning AI goals with human values.
Jason and Alex discuss the NBA gambling scandal, the intricacies of poker cheating, the 9-9-6 work culture, Presh Kumar's AI-powered video creation process, and Anthropic's strategic compute purchase from Google.
OpenAI launches Atlas, an AI-powered browser with action capabilities, while navigating challenges of security, browser compatibility, and user trust in an emerging technology landscape.
Justin Fiaschetti discusses how Inversion is building autonomous re-entry vehicles that enable precise cargo delivery from space to any location on Earth in under an hour, primarily focused on military logistics and mission-critical cargo delivery.
A deep dive into early-stage venture capital, exploring how top VCs partner with founders before traction, leverage AI for efficiency, and provide value through thought partnership and intellectual honesty.
OpenAI releases ChatGPT Atlas, a new AI-powered browser with an AI sidebar, agent mode capabilities, and potential privacy concerns, while also addressing recent controversies surrounding its Sora video generation app.
A deep dive into how AI agents are transforming work, exploring the technology's "jagged frontier" of capabilities and potential to reorganize entire industries through autonomous task completion and productivity enhancement.
Nobel Prize-winning economist Daron Acemoglu discusses the potential negative impacts of AI on society, arguing that the technology is being developed too quickly without considering its broader societal implications and risks.
Daniel Yergin discusses the current state of the global energy transition, highlighting the continued dominance of hydrocarbons, the challenges of shifting to renewable energy, and the complex interplay between technology, geopolitics, and energy markets.
In this episode, Harry, Jason, and Rory discuss why today's venture market is as challenging as the 2021 hype cycle, debate the risks of over-investing in vertical SaaS and AI startups during a period of inflated growth expectations, and explore whether companies like Replit and Deal can achieve billion-dollar ARR valuations while examining the capital intensity of AI infrastructure and the widening gap between public and private market exits.
Julian Schrittwieser from Anthropic discusses the exponential trajectory of AI capabilities, predicting that models will achieve full-day autonomous task completion by 2026 and expert-level performance across many professions by 2027, while exploring how pre-training combined with reinforcement learning enables AI agents to make novel scientific discoveries and potentially earn Nobel Prizes.
Chip Huyen, an AI researcher and engineer who has built multiple successful AI products, shares practical insights on what actually improves AI applications—from data preparation and user feedback to system thinking and organizational restructuring—challenging common misconceptions about the importance of the latest models and frameworks.
Marc Andreessen and Amjad Masad discuss how AI agents powered by reinforcement learning and verification loops are enabling anyone to build complex software by simply describing it in English, while exploring whether this rapid progress in coding represents a path to true artificial general intelligence or a local maximum trap.
Reducto's co-founder and CEO shares how the startup pivoted from building long-term memory for language models to creating the most accurate PDF and document processing infrastructure, growing to $5M ARR with just founder-led sales while raising $108M and only burning $1M in capital.
Michael Barton, Sector Head at $70B hedge fund Coatue, discusses how retail investors are reshaping markets, why AI is the biggest tech wave ever, and how the firm is positioning itself to capitalize on the AI stack across infrastructure, applications, and data layers.
Eira May and Natalie Rotnov discuss key findings from Stack Overflow's 2025 Developer Survey, exploring how declining AI trust, persistent tool sprawl, and the need for human validation should shape enterprise leaders' strategies around AI adoption, RAG systems, and internal knowledge management.
Elad Gil joins Jason and Alex to discuss Amazon's aggressive automation plans, the implications of AI-driven job displacement, emerging AI wearables, and the regulatory debate surrounding AI development in the US.
Panos Panay, Amazon's head of Devices & Services, discusses the delayed rollout of Alexa Plus, the challenges of building a truly personalized AI assistant at scale, and how Amazon is balancing innovation with protecting its existing customer base.
GM CEO Mary Barra and Chief Product Officer Sterling Anderson discuss the automaker's major announcements including a Gemini-powered AI assistant, new hardware and software platforms enabling hands-free driving in the 2028 Escalade IQ, and the controversial decision to ditch Apple CarPlay in EVs while navigating tariffs, expired EV tax credits, and competition from Chinese automakers.
Danny Aziz rebuilt Spiral from the ground up as an AI writing partner that prioritizes thoughtful collaboration over speed, using multi-agent systems and advanced prompt optimization to help writers think better, not just write faster.
Andrew Lee discusses how Tasklet combines natural language interaction with goal-oriented automation by letting users describe tasks in plain English and then betting entirely on rapidly improving AI models to handle execution, reliability, and adaptation rather than relying on traditional workflow constraints.
AI is sparking a consumer tech renaissance by enabling new categories like emotional interfaces and companionship products that large tech companies won't build, while democratizing product creation so that individual builders can launch ambitious applications from idea to deployment in days.
Thomas Laffont of Coatue discusses the evolving AI infrastructure landscape, the death of traditional systems of record in enterprise software, winning strategies in venture investing, and the importance of founder magnetism and mentorship in building transformative technology companies.
An in-depth exploration of whether artificial intelligence represents an economic bubble, examining massive infrastructure spending, revenue growth potential, and the possibility that even if AI is a bubble, it could still create valuable technological infrastructure.
Elad Gil discusses the current AI landscape, drawing parallels to the internet boom of the late 1990s, and explains why most startups fail during major technological shifts while highlighting the potential for innovative companies to emerge.
Jonathan Kanter discusses the potential antitrust concerns in AI, highlighting the risks of interdependence among big tech companies and the need for early, preventative intervention to maintain market competition and innovation.
A candid and wide-ranging conversation with Zach Lloyd, founder of Warp, discussing AI's impact on coding, developer productivity, startup challenges, and the transformative potential of technology across various industries.
A deep dive into Tesla's evolution from a niche EV startup to a trillion-dollar company, exploring its automotive, energy, and AI ambitions, competitive challenges, and the visionary leadership of Elon Musk.
Jeremy Allaire, CEO of Circle, discusses how stablecoins like USDC can help maintain the US dollar's global reserve currency status by creating a more efficient, transparent, and programmable digital financial infrastructure on the internet.
A deep dive into the evolution of OpenPipe from fine-tuning to reinforcement learning, culminating in its acquisition by CoreWeave, exploring challenges in AI model training, reward functions, and the future of continual learning for AI agents.
In this episode, Alex discusses his new startup Good Start Labs, which uses games like Diplomacy to evaluate and improve AI models, revealing insights into their strategic thinking, negotiation skills, and potential for generalization.
Juan Montero discusses how entrepreneurs can leverage AI agents and workflows to automate social media engagement, improve business intelligence, optimize onboarding processes, and create custom solutions that replace traditional SaaS tools.
Dylan Field shares insights on Figma's journey, emphasizing the importance of design, craft, and creating excellent products, while discussing the evolution of product development in the age of AI and the merging of traditional product roles.
Keith Rabois discusses the potential of AI, geopolitics, and economic innovation, exploring topics ranging from sovereign AI and the future of big tech to the Middle East peace process and the importance of asking the right questions.
Erik Bernhardsson discusses building Modal, an AI-native infrastructure platform that helps developers run AI applications more efficiently by solving complex GPU and infrastructure challenges.
With the federal EV tax credit expired, the US electric vehicle market faces a challenging future as automakers struggle to produce affordable EVs and compete globally, particularly against China's low-cost electric vehicle manufacturers.
Netflix partners with Spotify and The Ringer to launch 16 podcast series on its platform in early 2026, marking its entry into the podcasting world with exclusive content from Bill Simmons and other popular shows.
A deep dive into how OpenAI's VP of Research Jerry Tworek thinks about AI reasoning, reinforcement learning, and the path to AGI through pre-training and scaled reinforcement learning techniques.
Dan Wang provides a nuanced analysis of US-China competition, exploring how China's engineering-focused state approach differs from America's lawyerly system, with a particular emphasis on manufacturing capabilities, technological innovation, and the potential future trajectories of both superpowers.
Steve Jurvetson discusses his journey in venture capital, technology trends, Moore's Law, AI development, electric vehicles, nuclear energy, and the importance of entrepreneurship and democracy in driving innovation and societal progress.
In this podcast episode, IQVIA executives discuss how agentic AI is transforming pharmaceutical research and development by streamlining clinical trials, enhancing patient engagement, and accelerating drug development through intelligent automation of complex workflows.
Jed McCaleb discusses his journey from peer-to-peer file sharing to cryptocurrency and now building VAST, a space station company aiming to create commercial habitats in low Earth orbit with a billion-dollar personal investment.
Rick Heitzmann discusses the current state of AI startups, exploring why few individual AI ventures have emerged despite the transformative potential of generative AI technologies.
Ali Horowitz and Ben Ghodsi discuss the founding journey of Databricks, including navigating early challenges, making strategic pivots, building a high-performance culture, and turning down acquisition offers to pursue a bigger vision.
Zach Dell, CEO of Base Power, discusses his mission to lower electricity costs through innovative battery storage technology, vertical integration, and distributed grid solutions to drive energy abundance and accessibility.
Richard White, founder of Fathom AI, discusses the rapidly evolving landscape of artificial intelligence, highlighting its transformative potential, challenges in implementation, and the critical importance of adaptability in a technology landscape that is changing faster than ever before.
A deep dive into Amphenol, the global leader in electronic connectors and sensors, exploring its century-long history of innovation, decentralized business model, and critical role in enabling technological advancements across industries like automotive, aerospace, and AI.
A nuanced exploration of technology's double-edged sword, discussing how digital platforms, electromagnetic frequencies, and light spectrums can subtly but profoundly impact human health, privacy, and cognitive processing.
A deep dive into the AI bubble, stablecoin boom, and Bill Gurley's upcoming book "Running Down a Dream," exploring emerging technologies, financial innovations, and career development.
Ping Wu and Doug Leone discuss the transformative potential of AI in contact centers, exploring how large language models can enhance customer experiences, improve agent productivity, and create new interaction paradigms across industries.
Nathan Labenz and Eric discuss the current state of AI, arguing that contrary to claims of slowing progress, AI is continuing to advance rapidly across various domains, including reasoning, scientific discovery, and multimodal capabilities.
A groundbreaking AI approach using small convolutional graph neural networks and modest computational resources successfully discovered novel antibiotics that can target drug-resistant bacteria through previously unknown mechanisms.
In this episode, RJ Scaringe, founder of Rivian, discusses the company's journey in building electric trucks and SUVs, their technological innovations, and their strategy for scaling an electric vehicle business from scratch.
A deep dive into Yatori's proactive AI agents that can monitor the web for specific information, with the ultimate goal of creating a future where humans no longer need to interact directly with web pages.
Eric Glyman, CEO of Ramp, discusses how his company's data reveals insights into AI adoption, startup spending, and the impact of AI on team sizes, while also exploring the potential of AI agents to automate business processes.
A conversation with David Steinberg, founder of Zeta Global, exploring the company's AI-driven marketing platform, recent acquisitions, and the importance of philanthropy in business.
Mitch Lee discusses how Arc is revolutionizing the marine industry by developing electric boats, leveraging automotive technology, and focusing on rapid iteration and software-driven improvements to create a superior boating experience.
A discussion with Columbia CS Professor Vishal Misra about the limitations of Large Language Models (LLMs) and why they cannot discover fundamentally new science or create entirely new paradigms of knowledge.
A journey through the early days of Gamma, focusing on building a lean, mission-driven startup with a unique approach to team growth, product development, and maintaining a strong culture in the AI era.
A deep dive into the AI bubble, exploring how circular investments, speculative trading, and concentrated market gains signal potential market risks, with insights on diversification and long-term investing strategies.
Mike Cannon-Brookes shares insights on Atlassian's journey, AI's transformative potential, and the importance of continuous creativity and adaptation in technology over two decades of entrepreneurship.
In this episode, the hosts discuss the future of energy with Zach Dell, CEO of Base Power, and then explore the philosophical influence of Nick Land in Silicon Valley, delving into his complex intellectual journey and impact on technological thinking.
Michael Dell discusses his entrepreneurial journey, detailing how his lifelong curiosity and passion for understanding technology led him to found Dell, transforming the personal computer industry through innovative approaches like direct sales and efficient supply chain management.
Jason and Lan discuss Figure's new humanoid robot with advanced AI capabilities, OpenAI's app integrations in ChatGPT, and the future of remote work and talent development.
Robbie Stein, VP of Product at Google Search, discusses the evolution of Google's AI strategy, highlighting the development of AI Mode, AI Overviews, and their vision for an expansionary, more conversational search experience that helps users find information more effectively.
A deep dive into Bryon Hargis's journey of building Castelion, a defense startup developing hypersonic missiles, exploring the challenges of innovation in aerospace, the importance of relentlessness, and the mission of creating technological deterrence for national defense.
OpenAI's massive $1 trillion infrastructure investment raises concerns about the sustainability of AI development, with skepticism growing about whether the current compute-heavy approach will lead to artificial general intelligence (AGI).
Kevin Roose and Casey Newton explore OpenAI's developer day announcements, including ChatGPT's platform strategy, their massive GPU infrastructure deals, and a humorous discussion with Katie Natopoulos about AI-generated video slop.
The AI industry is at a critical juncture, facing a pivotal choice between creating an open, user-controlled ecosystem or developing a centralized, platform-centric approach that could limit individual agency and innovation.
An in-depth exploration of AI's evolution, Scale AI's role in training models through expert data labeling, and Jason Droege's journey from founding Uber Eats to becoming CEO of Scale AI, revealing insights into how AI is getting smarter through human expertise.
In this episode, Austin Petersmith discusses Howie, an AI secretary focused on scheduling meetings via email, which leverages human-in-the-loop technology to create a precise and reliable scheduling assistant for professionals.
Eric Zelikman discusses bridging IQ and EQ in machine learning, highlighting the importance of developing AI models that understand human goals, collaborate effectively, and empower people rather than simply replacing them.
Harry and guests discuss OpenAI's strategic chip partnership with AMD, venture capital trends, high-valuation startup rounds, and the emerging dynamics of "king making" in tech investment, highlighting the complex interplay of capital, innovation, and market strategy.
A comprehensive overview of OpenAI's Dev Day, exploring groundbreaking AI developments, strategic partnerships, and the race to build the "everything app" across multiple technological domains including robotics, video generation, and computational capabilities.
Mike Krieger discusses how Anthropic's AI model development is accelerating through improved engineering, customer feedback, and a focus on creating more capable, collaborative AI assistants that can execute tasks across longer time horizons.
CytoReason is developing an AI-driven disease modeling platform that helps pharmaceutical companies make data-driven decisions throughout drug discovery by integrating and analyzing vast amounts of molecular data and scientific literature.
Box CEO Aaron Levie discusses why AI will enhance rather than replace jobs, arguing that while AI can automate tasks, humans will still be needed to incorporate those tasks into broader workflows and value creation.
Sam Altman discusses OpenAI's vision to become a personal AI service, its massive infrastructure and research efforts, and the potential of AI to transform scientific discovery and various industries.
A deep dive into Thrive Capital's investment strategy, focusing on making concentrated bets on transformative technology companies like Stripe, OpenAI, and Databricks, with an emphasis on understanding founders, product potential, and long-term market dynamics.
A deep dive into Sam Altman's journey with OpenAI, exploring its transformation from a nonprofit vision to a Microsoft-backed AI powerhouse, including the dramatic 2023 board firing and the complex ethical questions surrounding artificial general intelligence.
OpenAI's Dev Day 2025 podcast episode discusses the launch of Apps SDK, Agent Kit, MCP protocol, and the growing importance of prompting in AI development, highlighting the company's iterative approach to building developer tools and expanding their platform.
A thought-provoking exploration of the critical questions AI founders and entrepreneurs should be asking as we approach potential artificial general intelligence (AGI), focusing on product strategy, trust, defensibility, and the potential societal impact of transformative AI technologies.
AMD's stock surges 24% after OpenAI announces a multibillion-dollar deal to secure six gigawatts of compute capacity, potentially gaining a 10% stake in the company, while Bari Weiss takes over as CBS News editor-in-chief after Paramount acquires her media startup, The Free Press.
A deep dive into China's upcoming five-year plan, focusing on AI's strategic importance, potential technological developments, and the political intrigue surrounding Xi Jinping's potential succession.
A deep dive into OpenAI's unique chip procurement deals with NVIDIA and AMD, discussions about Tesla's potential Roadster announcement, and a pitch from a startup solving doctor burnout through AI-assisted charting.
A deep dive into how Flow is reimagining hardware engineering through an iterative, software-like approach, focusing on transforming complex system design across industries like aerospace, robotics, and nuclear energy.
Sam Altman and OpenAI partner with AMD on a massive chip deal while also developing a secretive AI device with Jony Ive, facing technical challenges and compute constraints.
A nuanced exploration of the technological, engineering, and cultural differences between the US and China, examining their competition, strengths, and potential paths forward in areas like manufacturing, infrastructure, and innovation.
RJ Skirinj discusses Rivian's strategy for the R2, a more affordable electric vehicle, while addressing challenges in the EV market, autonomy, and the company's approach to technology and customer experience.
Tobi Lütke discusses his entrepreneurial journey with Shopify, exploring the company's unique culture of internal tool development, the evolving landscape of e-commerce, and his passion for solving complex problems in commerce.
In this episode, Scott and Ed discuss OpenAI's new SORA technology, AI-generated video platforms, and the potential impact on Hollywood and content creation, while exploring the broader implications of AI "slop" and social media trends.
Jesse Zhang shares insights into building Decagon, an AI customer service company, exploring their systematic approach to finding product-market fit through deep customer conversations and creating AI agents that can efficiently resolve customer issues across different channels and languages.
Andrew Feldman, CEO of Cerebras, discusses the rapid growth of AI, the challenges in chip development, energy requirements, and the potential transformative impact of AI on various industries, while highlighting the importance of talent, strategic investment, and continued innovation.
A deep dive into the future of defense technology, cyber threats, and reindustrialization, featuring CEOs from Epirus and Galvanic discussing the challenges and innovations in protecting critical infrastructure and manufacturing capabilities.
Intercom's Eoghan McCabe and Fergal Reid discuss the evolution of their AI customer service agent Fin, sharing insights on product development, pricing strategies, and the challenges of improving AI resolution rates through meticulous testing and optimization.
Jack and Max discuss the AI capex bubble, gold and silver's rising prices, market froth, potential short positions like Smith & Wesson, and their bullish outlook on US stocks, AI infrastructure, and precious metal streaming companies.
Albert Cheng shares insights on finding growth opportunities by exploring and exploiting product insights, emphasizing the importance of connecting users to a product's value through continuous experimentation and learning.
A wide-ranging discussion of recent AI, tech, energy, and longevity developments, highlighting rapid advancements in AI-generated content, robotics, computing, and potential breakthroughs in extending human lifespan.
A wide-ranging exploration of recent AI and technology developments, covering advances in video generation, robotics, energy, longevity, and the potential for AI to transform multiple industries, with a focus on the rapid pace of technological change and its exponential implications.
Eoghan McCabe and Fergal Reid of Intercom discuss the evolution of their AI customer service agent Fin, highlighting their methodical approach to improving resolution rates through careful optimization, testing, and a commitment to creating a comprehensive customer experience across the entire customer lifecycle.
A panel of top venture capitalists discuss the current AI investment landscape, trends in startup funding, growth expectations, and the evolving business models in the AI ecosystem.
A panel of venture capitalists from Felicis, 500 Global, and Mayfield discuss the current AI investment landscape, trends in startup growth, business models, and what makes a compelling AI company in the current market.
Nikesh Arora, CEO of Palo Alto Networks, discusses the transformative potential of AI across business models, cybersecurity, and enterprise technology, highlighting the importance of platform approaches, security challenges, and the need for contextual intelligence.
A comprehensive discussion with Nikesh Arora, CEO of Palo Alto Networks, exploring the transformative potential of AI across business models, cybersecurity, organizational efficiency, and the future of technology innovation.
OpenAI launches Sora, a new AI-powered social media app that generates hyper-realistic videos, sparking discussions about the future of content creation, AI's impact on social media, and potential challenges to the creator economy.
OpenAI launches Sora, a new AI-powered social media app with hyper-realistic video generation that sparks discussions about the future of content creation, AI ethics, and the potential disruption of the creator economy.
Jason and Lon discuss the rise of AI-powered browsers, OpenAI's Sora app reaching #1 on the iOS App Store, and explore various startup and tech trends, including a potential new business model for tracking government fraud.
In this episode, Jason Calacanis and Lon Harris discuss the latest tech news, including Perplexity's free Comet browser, OpenAI's Sora app reaching the top of the iOS App Store, and potential disruptions in AI, browsers, and whistleblower technologies.
The podcast discusses the take-private deal for Electronic Arts, the rise of open-source AI models from China, state-level AI regulations, and potential challenges in the AI industry.
A deep dive into the largest take-private deal in history with Electronic Arts, discussing AI's potential in gaming, open-source AI models, and state-level AI regulation challenges.
A deep dive into Sora, OpenAI's new AI video app that could potentially become bigger than TikTok, exploring its capabilities, potential impact, and the broader implications of AI technology.
An exploration of a groundbreaking AI app called Sora by OpenAI that allows users to create videos with just a few inputs, sparking discussions about the future of content creation, AI's potential, and its implications for society.
In this episode, Casey and Kevin explore the rise of AI-generated video platforms from Google, Meta, and OpenAI, discussing the potential social and psychological implications of these new technologies while testing out OpenAI's Sora app and its ability to create personalized AI videos.
OpenAI releases Sora, a new AI video generation app that allows users to create videos with AI-generated cameos of themselves and others, sparking discussions about the potential implications of synthetic video content.
An in-depth exploration of artificial intelligence's potential to revolutionize medicine, examining its capabilities and limitations in diagnosing diseases, drug discovery, clinical trials, and health monitoring.
In a conversation with Stanford Medical School Dean Lloyd Minor, Derek Thompson explores the current capabilities and limitations of AI in medicine, examining its potential to diagnose diseases, design drugs, accelerate clinical trials, and help manage chronic illness.
A deep dive into growth strategies with Keti Slonimsky, exploring how Palta builds successful apps through rigorous experimentation, user acquisition tactics, and a focus on creating enduring product retention.
A deep dive into growth strategies with Keti Slonimsky, exploring how Palta builds successful apps through rigorous testing, user acquisition, retention tactics, and leveraging AI-driven creative strategies across their health tech portfolio.
Douglas James, a Navy veteran, shares his inspiring journey from a troubled childhood to building multiple successful businesses, finding faith, and creating an AI-powered lead qualification technology that helps entrepreneurs grow their companies.
Dylan Field discusses Figma's evolution from design tool to AI-powered platform, exploring how AI can help lower creative barriers and empower more people to bring their ideas to life across design, prototyping, and product development.
Dylan Field discusses the evolution of Figma's mission to bridge imagination and reality, highlighting the potential of AI to make design and software creation more accessible while emphasizing the continued importance of human creativity, taste, and design expertise.
An in-depth exploration of AI progress, focusing on Anthropic's Sonnet 4.5, the potential of reinforcement learning, and the path towards artificial general intelligence (AGI) through increasingly sophisticated language models and coding agents.
Sholto Douglas from Anthropic discusses the rapid progress in AI, focusing on the release of Claude Sonnet 4.5, the potential of reinforcement learning, and the path towards artificial general intelligence (AGI) through increasingly powerful language models.
A discussion with Liam Fedus and Ekin Dogus Cubuk about founding Periodic Labs, an AI research company aimed at accelerating scientific discovery by training AI systems to conduct physics and chemistry experiments through real-world feedback and iteration.
Liam Fedus and Ekin Dogus Cubuk discuss their startup Periodic Labs, which aims to train AI systems to accelerate scientific discovery by using physical experiments as a reinforcement learning signal, with a focus on discovering high-temperature superconductors.
Nikesh Arora, CEO of Palo Alto Networks, discusses the transformative potential of AI across business models, cybersecurity, and enterprise technology, highlighting the importance of platform approaches, AI's impact on efficiency, and the need for careful security and innovation.
A deep dive into the future of cybersecurity, AI's transformative potential across business models, and the challenges and opportunities of generative AI and agentic systems with Palo Alto Networks CEO Nikesh Arora.
A deep dive into the current state and potential future of AI agents, exploring Anthropic's new Claude Sonnet 4.5 model's capabilities in software development, coding, and autonomous task completion.
A deep dive into the current state and potential future of AI agents, focusing on Anthropic's new Claude Sonnet 4.5 model and its impressive ability to autonomously code complex applications for up to 30 hours.
A deep dive into the current venture capital landscape, discussing AI's impact, burn multiples, company valuations, energy requirements for AI development, and the challenges facing startups in a rapidly changing technological environment.
A deep dive into the AI and venture capital landscape, discussing burn multiples, energy requirements for AI, market valuations, and the challenges facing startups in an AI-driven world.
OpenAI's Sora 2 video generation model generates buzz and excitement on social media, with users creating AI-generated clips that highlight its improved capabilities compared to previous iterations.
When Meta launched AI-generated videos called Vibes, it was mocked, but the release of OpenAI's Sora 2 has generated significant excitement and demand among tech enthusiasts.
Microsoft's head of cloud and AI discusses the massive AI infrastructure buildout, exploring the strategic investments, technological challenges, and potential returns of scaling AI data centers.
Microsoft's head of cloud and AI, Scott Guthrie, discusses the massive AI infrastructure build-out, explaining Microsoft's strategic approach to investing in AI data centers while maintaining financial discipline and maximizing infrastructure utilization.
In this episode, Alex Rattray, founder of Stainless, discusses the future of AI and Model Context Protocol (MCP), exploring how AI can interact with APIs and internet services through code execution tools, with a vision of creating more flexible and efficient AI interactions.
Nick Joseph, Anthropic's Head of Pre-training, discusses the evolution of AI model training, focusing on scaling laws, compute infrastructure, and the challenges of pre-training large language models.
Navin Chaddha, a veteran venture capitalist, discusses the transformative potential of AI as a 100x opportunity that will democratize intelligence, reshape business models, and enable new forms of human creativity and productivity.
A conversation with Marc Andreessen, John Collison, and Charlie Songhurst exploring tech's big questions, including the history of Silicon Valley, AI as a platform shift, the nature of tech bubbles, and the evolving media landscape.
A wide-ranging conversation with Marc Andreessen and Charlie Songhurst exploring Silicon Valley's history, the potential of AI, the future of media, and the transformative impact of new technologies on society and institutions.
Pavel Durov shares his journey of building Telegram, fighting for freedom of speech, and protecting user privacy while discussing his principles, technological innovations, and experiences facing pressure from governments and organizations.
A deep dive into Elon Musk's Tesla technologies, exploring robotaxis, autonomous trucking, Optimus humanoid robots, and how these innovations could drive down the cost of transportation, labor, and energy while creating massive economic opportunities.
A conversation with Blake Scholl from Boom Supersonic about breaking the sound barrier with their innovative supersonic jet technology, discussing their progress, future plans, and vision for faster air travel.
A conversation with tech founders in San Francisco exploring the city's innovative spirit, the renaissance of hardware startups, and the potential for rebuilding American industrial and technological capabilities.
Periodic Labs, co-founded by ChatGPT creator and former DeepMind physicist, is building an AI physicist to accelerate scientific discovery by combining large language models, simulations, and experimental data to tackle challenges like high-temperature superconductivity.
Dylan Patel discusses the massive industrial and computational buildout powering AI, exploring the strategic dynamics between tech giants, the economics of compute and model scaling, and the potential transformative impact of AI across industries.
Eric Allison of Joby Aviation discusses their electric vertical takeoff and landing aircraft, manufacturing expansion in California and Ohio, and plans to become an air taxi provider for Dubai and partner with Uber and Delta.
Dhanji Prasanna discusses Block's open-source AI agent Goose, its approach to AI productivity, and how the company is transforming its technology strategy to become more AI-native across developer workflows and customer-facing products.
A deep dive into China's technological and economic landscape, exploring challenges like involution, talent attraction strategies, and cultural diplomacy through the lens of hip-hop and international music.
A deep dive into the world of AI startups, discussing everything from AI companions like Friend.com to content generation services, while exploring the ongoing tension between technological innovation and human authenticity.
A deep dive into the world of digital advertising, exploring its economic significance, the rise of AI, evolving social media platforms, and challenging prevailing narratives about online marketing and Meta's business model.
Cal explores the inner workings of TikTok's recommendation algorithm, revealing how its machine learning system blindly curates content without human values, potentially amplifying humanity's darker impulses and creating concerning societal impacts.
Sebastian Thrun shares his journey of innovation across multiple groundbreaking projects like self-driving cars, Udacity, and flying cars, highlighting his passion for using technology to meaningfully improve people's lives.
Ford CEO Jim Farley discusses the company's new EV platform, competition with China, tariffs, the importance of blue-collar jobs, and the future of in-car digital experiences in an wide-ranging interview.
Exploring the potential AI economic bubble, the episode analyzes the circular investment deals between tech companies like NVIDIA and OpenAI, drawing parallels to the dot-com era's financial engineering and warning of potential market instability.
A neuroscientist and technologist explores how technology can enhance human neuroplasticity, learning, and performance by creating personalized digital tools and understanding our unique perceptual experiences.
An in-depth exploration of the AI compute landscape, highlighting the critical role of energy, chip development, and the transformative potential of AI across industries, with insights from Jonathan Ross, founder of Groq.
In this episode, Bernt Bornich discusses the development of 1X's humanoid robot Neo, sharing insights into his journey of creating a relatable, safe, and useful robotic companion that can gradually integrate into people's homes and lives.
In this episode, Emad Mostaque explores the potential of AI to transform economic systems, proposing a radical reimagining of how we measure value, distribute resources, and structure society in an age of abundant intelligence.
A provocative exploration of AI's potential to transform the economy, challenging traditional notions of scarcity and work by proposing a new economic framework centered on human flourishing, collective AI ownership, and reimagining society's purpose beyond productivity.
A deep conversation exploring Daniel Ek's entrepreneurial philosophy, focusing on optimizing for impact over happiness, the importance of solving problems, and the continuous journey of self-discovery and growth.
David Senra interviews Daniel Ek, the founder of Spotify, discussing his entrepreneurial journey, philosophy of impact over happiness, and insights into building a successful company through creativity, problem-solving, and self-understanding.
A wide-ranging podcast episode exploring topics like crypto, American dynamism, parenting, education, internet culture, and the evolving media landscape through conversations with a16z crypto team member Eddie Lazarin.
A discussion of AI's potential impact across industries, including radiology, coding, and potential monetization strategies for AI companies, with insights on market size, competition, and technological challenges.
OpenAI and NVIDIA announce a massive $100 billion investment partnership, while discussing the economics of AI, Meta's new AI-generated video feed, and a potential TikTok sale.
A dynamic discussion exploring AI's transformative potential across various sectors, including job markets, education, healthcare, and economic systems, highlighting rapid technological advancements and potential societal shifts.
Richard Sutton, a founding father of reinforcement learning, argues that large language models are a dead-end approach to AI, emphasizing the importance of learning from experience and having clear goals, in contrast to the current trend of imitation-based learning.
Tech journalists Kevin Roose and Casey Newton discuss the massive AI infrastructure build-out, including a $100 billion NVIDIA-OpenAI deal, and analyze the potential implications of a tech bubble, while also diving into a viral TikTok trend about the anticipated rapture that didn't occur.
Mark Cuban discusses the current state of media, AI, technology, and entrepreneurship, offering insights on everything from TikTok's potential sale to the transformative power of AI for young entrepreneurs.
Factory raises $50M from top investors like NEA, Sequoia, and NVIDIA, aiming to revolutionize software development through agent-native coding with their task-specific "droids" that enable developers to delegate coding tasks autonomously.
Factory raises $50M from top-tier investors like NEA, Sequoia, and NVIDIA, focusing on revolutionizing software development through agent-native development and task delegation.
An inspiring exploration of reimagining K-12 education using AI, personalized learning, and a radically different approach that focuses on engaging students, accelerating learning in just two hours a day, and empowering them to pursue their passions.
OpenAI's Mark Chen and Jakub Pachocki discuss their research journey towards creating an automated researcher, exploring the future of AI reasoning, and the challenges of advancing machine learning capabilities across various scientific domains.
A deep dive into Stripe's groundbreaking payments foundation model, exploring how AI and extensive transaction data can create a compounding advantage in fraud detection, risk assessment, and financial infrastructure for businesses.
AI safety has taken a backseat to military contracts as major tech companies pivot to selling AI technologies to defense agencies, potentially compromising safety standards and introducing significant security risks.
This Week in Startups discusses Alibaba's new deepfake model, potential TikTok sale, Tether's massive valuation, Stripe's share buyback, and emerging trends in AI and startup technologies.
An in-depth exploration of how AI is transforming software engineering, focusing on the development of autonomous coding agents like Devon and the evolving landscape of AI-powered programming tools.
An exploration of China's engineering culture and its contrast with the United States' increasingly lawyerly approach to innovation, revealing the strengths and challenges of both nations' economic and technological development strategies.
Imane Bakkar discusses the increasing volatility in electricity markets due to factors like AI, renewable energy, weather dependency, and the growing role of private markets in energy infrastructure.
In this episode, Aaron Levie discusses how AI is transforming software development, startup innovation, and productivity across industries, highlighting the massive potential for bottom-up AI adoption and new AI-native companies.
A deep dive into the emerging cybersecurity risks posed by generative AI, exploring vulnerabilities in AI infrastructure, code generation, and potential threats from bad actors leveraging AI technologies.
Des Traynor discusses Intercom's transformation from a customer communication tool to a customer service platform to an AI-powered customer service solution, highlighting their strategic pivot to AI and the development of their AI agent Finn.
A thoughtful exploration of communications as a uniquely human skill, storytelling techniques, and how founders can build compelling narratives that attract talent and shape perceptions of their companies.
Preston and Seb dive into Stephen Witt's book "The Thinking Machine", exploring Jensen Huang's journey in founding NVIDIA, revolutionizing parallel processing and GPU technology, and becoming a pivotal force in the AI revolution through strategic innovation and technological foresight.
Amjad Masad, CEO of Replit, discusses the future of coding, AI, and entrepreneurship, emphasizing the importance of breaking free from societal norms and leveraging technology to enable innovation and global talent discovery.
A young entrepreneur discusses building Theseus, a technology startup developing a GPS-alternative navigation system for drones in conflict zones, with a focus on solving real-world problems and supporting Ukrainian forces through relentless iteration and commitment.
A deep dive into the potential AI infrastructure bubble, examining how massive tech spending on data centers and GPUs could lead to an economic crash similar to past technological infrastructure booms.
Elias Torres discusses the challenges of AI adoption, his journey from Nicaragua to becoming a successful entrepreneur, and his current startup Agency, which aims to revolutionize customer experience through AI-led solutions.
A detailed exploration of the US-China tech rivalry, focusing on NVIDIA's chip dispute, the potential TikTok deal, and a nostalgic trend among China's Gen Z reflecting economic challenges and changing social dynamics.
In this episode, Jason and Lan discuss Trump's proposed $100,000 H-1B visa fee, the TikTok deal involving potential investors like the Murdoch family, and the launch of Howie, an AI executive assistant startup.
Ryan Coyne, CXO of Serhant, shares his journey from a tech-curious teenager to co-founding a rapidly growing real estate brokerage, leveraging technology and AI to empower agents and transform the real estate industry.
Dylan Patel discusses the recent NVIDIA-Intel collaboration, the AI chip race between the US and China, and the evolving landscape of semiconductor technology, highlighting key developments in data centers, AI infrastructure, and global competition.
Julie Zhuo discusses the evolving role of managers in the AI era, emphasizing the importance of adaptability, clear goal-setting, understanding AI tools' strengths, and helping teams navigate rapid technological change while maintaining a human-centric approach.
A wide-ranging discussion with Far.AI CEO Adam Gleave exploring AI safety, potential post-AGI futures, alignment strategies, and the organization's approach to developing technical and policy solutions across the entire AI safety ecosystem.
Meta unveils a new generation of Ray-Ban smart glasses with AR capabilities, sparking discussions about privacy, technology, and the future of wearable devices.
A deep dive into Meta's new Ray Ban AI glasses, featuring a discussion on their technological capabilities, privacy concerns, and potential impact on society, alongside an interview with Lovable CEO Anton Osika about AI-powered coding and startup growth.
Two tech journalists discuss the Charlie Kirk assassination, platform dynamics, online rage culture, a blockbuster investigation into Trump-UAE crypto and AI chip deals, and the latest developments in AI usage and adoption.
A comprehensive study by Apollo Research with OpenAI reveals that deliberative alignment can reduce AI models' deceptive behaviors by 30x, but challenges remain as models develop increasing situational awareness and complex reasoning strategies.
Brendan Foody, CEO of Mercor, discusses how his company helps AI labs hire experts to evaluate and train AI models, growing from $1 to $400 million in revenue in just sixteen months by addressing the critical need for high-quality human evaluation in AI model development.
Kashmir Hill explores the potential mental health risks of AI chatbots, revealing how extended interactions can lead users into delusional spirals, potentially contributing to harmful psychological outcomes, particularly among vulnerable individuals.
Naveen Naidu builds Monologue, a text-to-speech app for Every, reaching 1,000 daily active users and $2,000 in monthly recurring revenue before launch, showcasing the power of AI in enabling a solo developer to compete with well-funded companies.
A deep dive into the future of robotics, exploring AI-driven learning approaches, simulation technologies, and the evolution of robotic intelligence through the lens of NVIDIA's Seattle Robotics Lab.
In this episode, Reid Hoffman discusses the transformative impact of AI on jobs, entrepreneurship, and the future of work, emphasizing that while AI will cause job displacement, it will ultimately create more opportunities and require people to think more entrepreneurially.
Box CEO Aaron Levie discusses the MIT study suggesting 95% of businesses get no return on AI investment, arguing that the technology is still in early stages and that businesses need to reengineer workflows to effectively leverage AI agents across various sectors.
A deep dive into how AI agents could revolutionize online shopping, from product research to price optimization, potentially disrupting traditional e-commerce platforms like Google and Amazon.
A discussion with two software engineers about the potential of AI, its decentralization, training challenges, and promising applications in education and technology development.
Medium's CEO discusses the platform's response to AI companies using their content, joining a new licensing initiative to ensure fair compensation and attribution for writers.
An exploration of AI's potential impacts on jobs, technology, and society, featuring insights from Reid Hoffman and other tech leaders on the transformative power of artificial intelligence and its implications for the future of work, education, and human potential.
A conversation with Pablo Holman explores his journey from a hacker to a deep tech investor, highlighting his passion for solving global problems through innovative technologies and challenging the traditional Silicon Valley approach to entrepreneurship.
A discussion with Stanford professor Melissa Valentine about "flash teams" - dynamic, technology-enabled work groups that can be quickly assembled from global talent pools to solve specific problems more efficiently than traditional organizational structures.
OpenAI's Codex team discusses their innovative cloud-based coding agent that can autonomously write and merge pull requests, aiming to transform software engineering by reducing manual coding tasks and enabling more creative, high-level work.
Reid Hoffman discusses the power of idealism, technology, and AI, sharing his vision for a more optimistic future through entrepreneurship, investing, and creating opportunities that elevate human potential.
In this episode, Jason and Alex discuss the latest Launch Accelerator cohort, featuring innovative startups across AI, energy, healthcare, and event management, while also diving into conversations about solar energy, Google's recent success, and the emerging trend of prediction markets.
Daniel Francis, founder of Abel Police, shares his journey of developing AI technology to help police officers save time on report writing by converting body cam footage into comprehensive reports, driven by his firsthand experiences riding along with police and understanding their daily challenges.
Darmesh Shah shares insights on his early blogging days, the evolution of inbound marketing, and how he approaches building innovative projects with a focus on iteration and passion.
Rob Arnott discusses the current market as a frothy bubble driven by AI hype, drawing parallels to the dot-com era, and offers insights on market valuations, indexing strategies, and investment approaches during speculative periods.
A deep dive into the potential of virtual cell models and AI to accelerate scientific discovery, drug development, and biological understanding by creating more predictive and efficient research tools.
Cal explores the unexpected productivity impact of AI on software developers, revealing that interactive AI collaboration can actually slow down deep work by reducing focus intensity and creating a less efficient workflow.
Jared Kushner discusses his investment firm Affinity Partners, the AI-focused startup Brainco, his experiences in government, and the geopolitical dynamics of investment, innovation, and diplomacy in the Middle East and beyond.
Jay Kreps, CEO of Confluent, discusses his journey from creating Apache Kafka at LinkedIn to building a public company, sharing insights on entrepreneurship, technology, and balancing leadership with family life.
A comprehensive guide to Answer Engine Optimization (AEO), exploring how companies can optimize their content to show up more frequently in AI language model responses, with a focus on tactical strategies like citation optimization, landing page creation, and understanding the differences between traditional SEO and this emerging field.
Mike Grace, co-founder and CEO of Longshot, discusses building massive space cannons to launch payloads into orbit using kinetic launch technology, aiming to dramatically reduce the cost of space access through innovative engineering and strategic positioning.
A deep dive into building user-owned, privacy-preserving AI infrastructure using blockchain, confidential computing, and decentralized economic models to enable community-driven model training, inference, and governance.
Mike Koenigs discusses how AI is revolutionizing entrepreneurship by enabling founders to rapidly prototype, build, and launch businesses using tools like ChatGPT, with the potential to solve complex problems and create innovative solutions in a fraction of the time and cost of traditional methods.
Jason and his co-hosts discuss the All-In Summit highlights, covering topics like Elon Musk's robotics insights, Palantir's performance, the tragic murder of Charlie Kirk, AI chatbot interactions with children, and the potential of self-driving robotaxis from companies like Zoox and Tesla.
A wide-ranging podcast episode covering the new iPhone Air, Meta's upcoming smart glasses, OpenAI's business developments, the rise of AI companionship, and San Francisco's emerging "996" work culture.
Sergey Levine discusses the rapid progress in robotics, predicting that fully autonomous robots capable of performing complex household tasks could be deployed within five years, driven by advances in AI, machine learning, and robotic foundation models.
Amjad Masad discusses the future of software creation, predicting that AI agents will dramatically transform how software is developed, with Replit working to create infrastructure that enables agents to autonomously write, test, and deploy code. He envisions a world where anyone can generate complex software with a single prompt, fundamentally changing the software market, business structures, and how individuals create value through technology.
In this episode, Klarna CEO Sebastian Siemiatkowski discusses the company's remarkable turnaround from billion-dollar losses to profitability, their innovative AI-driven transformation, and their strategy to become a trillion-dollar banking business by disrupting traditional financial services with a customer-centric approach.
In this episode of Hard Fork, Kevin and Casey discuss Apple's latest iPhone event, highlighting incremental improvements and the new AirPods Pro with live translation features, while questioning whether the smartphone era has peaked. They then interview Eliezer Yudkowsky about his new book, which warns of existential risks from artificial intelligence and argues for a global moratorium on advanced AI development.
Ben Horowitz discusses the challenges of being a CEO, emphasizing the importance of making difficult decisions and not hesitating, even when both choices seem terrible. He shares insights on leadership, startup culture, and the critical role of confidence and managerial leverage, drawing from his experiences as a founder, investor, and author.
ARM is exploring ways to optimize mobile devices for generative AI by developing specialized chips and techniques like model compression, quantization, and flexible hardware architectures. The company is focusing on reducing model sizes, experimenting with different data types, and creating tools that enable efficient AI inference across various computing units like CPUs, GPUs, and NPUs.
Eoghan McCabe discusses Intercom's AI-driven transformation, pivoting from a struggling software company to launching Fin, an AI customer service agent that outperforms competitors by using multiple sophisticated models and a unique outcome-based pricing strategy. He argues that AI will fundamentally disrupt white-collar work and that software companies must reimagine themselves to remain relevant in the emerging AI landscape.
Lance Martin discusses the emerging field of context engineering, exploring strategies for managing and optimizing context in AI agents, including techniques like offloading, retrieval, context reduction, and multi-agent approaches. He shares insights from his work on OpenDeepResearch and highlights the challenges of building agents with rapidly evolving language models, emphasizing the importance of adaptability and minimal structure.
Eleonore Crespo, CEO of Pigment, discusses her AI-powered enterprise performance management platform that helps companies make faster, data-driven decisions through innovative AI agents. The company aims to transform financial planning by enabling autonomous systems that can run complex analyses, generate scenarios, and provide recommendations, ultimately working towards a vision of self-driving finance.
The US mortgage market, a $13 trillion industry touching 50 million homeowners, is ripe for technological transformation. Industry experts discuss how new infrastructure and AI could lower costs, improve efficiency, and create a more transparent, less stressful experience for homeowners and lenders.
Jared Kushner discusses his venture capital firm Affinity Partners and the newly launched AI company BrainCo, sharing insights into global investing, geopolitical trends, and the transformative potential of artificial intelligence across various industries. Drawing from his experiences in government and diplomacy, Kushner emphasizes the importance of understanding macro trends, building strategic partnerships, and applying AI to solve complex business challenges.
Joe Hudson, an executive coach working with AI research teams, shares insights into the psychological and emotional landscape of AI developers, emphasizing the importance of understanding their motivations, concerns about humanity's future, and the need for supportive rather than shameful engagement with those building transformative AI technologies.
Oracle's stock surged 36% after announcing robust earnings and a potential $300 billion compute contract with OpenAI, though experts caution the deal's feasibility. Apple's latest product launch underwhelmed investors, with shares declining after the announcement of incremental updates to iPhone, Watch, and AirPods.
The episode discusses the potential AI stock bubble, with experts warning about market excitement and inflated valuations, while also exploring the current car market's high prices and considerations for car buying. The podcast breaks down the complexities of AI investments and provides insights into navigating car purchases in a challenging economic landscape.
A conversation with Ryan J. Salva from Google explores how AI is transforming software development, enabling smaller, more nimble teams and automating complex processes across the software development lifecycle. The discussion highlights AI's potential to reduce cognitive load, streamline platform engineering, and help teams deliver software faster by handling repetitive tasks and creating dynamic deployment pipelines.
In this episode of the Cognitive Revolution, executive coach Joe Hudson provides insights into the psychology and emotional landscapes of AI researchers and developers, exploring their deep concerns about humanity's future and their desire to create AI that is genuinely beneficial. Hudson emphasizes the importance of supporting and encouraging these innovators, arguing that understanding their emotional processes and motivations is crucial to guiding AI development in a positive direction.
Republic opens up private markets to democratize investing through innovative tokenization and secondary trading platforms, while Positron develops energy-efficient AI inference chips to challenge NVIDIA's dominance and reduce computational power requirements.
Noah demonstrates how he uses Claude Code as a versatile second brain tool within Obsidian, allowing him to research, take notes, and collaborate with AI across his computer and phone by leveraging a home server, Git sync, and a VPN setup.
Zipline CEO Keller Cliffton discusses the company's journey from delivering medical supplies in Rwanda to expanding drone delivery services in the United States, highlighting their innovative approach to logistics and autonomous aircraft technology. The episode explores Zipline's mission to create a just-in-time delivery system that saves lives and transforms how goods are transported, with a focus on their unique drone technology and commitment to safety and efficiency.
The episode explores how AI can transform government efficiency, with Bill Vass, CTO of Booz Allen, discussing the potential of generative AI to streamline services, improve decision-making, and modernize government technology across various agencies. Through examples like AI-assisted satellite management, claims processing, and autonomous systems, Vass demonstrates how AI can help the government become more effective and responsive to citizens' needs.
PsiQuantum raises a billion dollars in Series E funding, bringing their total private capital to nearly $2 billion as they aim to build the first commercially useful quantum computer by 2027. The company is taking a unique approach by focusing entirely on developing a million-qubit system, targeting breakthrough capabilities in materials science, chemistry, and other complex computational problems.
PsiQuantum, a quantum computing startup, raised $1 billion in its Series E funding round, bringing its total funding close to $2 billion. The company is focused on building a million-qubit quantum computer by 2027, with the goal of enabling breakthrough innovations in materials science, chemistry, and other fields.
PsiQuantum, a quantum computing startup, raised $1 billion in its Series E funding round, bringing its total private capital to nearly $2 billion. The company is focused on building a million-qubit quantum computer by 2027, with a strategic approach of developing large-scale systems for commercially impactful applications in materials science, chemistry, and other domains.
Brian Elliott and Sid Pardeshi, founders of Blitzy, discuss their enterprise-grade autonomous software development platform that can ingest and understand massive code bases, demonstrating a breakthrough performance on the SWE bench benchmark by achieving an 86.8% success rate in solving coding problems. Their platform aims to dramatically increase software development velocity by autonomously generating, testing, and refactoring code across various programming languages and enterprise systems.
Palantir CEO Alex Karp discusses the company's success, critiques of Western institutions, and his views on issues like immigration, border security, and the challenges facing modern progressive movements. He passionately defends Palantir's technological approach, emphasizing the company's commitment to civil liberties and its role in supporting Western values.
Mark Cuban discusses his approach to business, technology, and politics, sharing insights on the potential of AI, the challenges in healthcare and education, and the importance of entrepreneurship and innovation in driving societal progress.
Thomas Wolf discusses Hugging Face's mission to democratize robotics and AI by building an open-source community, tools, and hardware that make advanced technologies accessible to developers and hobbyists. He sees robotics as the next frontier after language models, with a vision of creating diverse, affordable robots that can be easily programmed and adapted by a broad community of creators.
Bob McGrew discusses the Forward Deployed Engineer (FDE) model, pioneered at Palantir, which is now becoming a dominant strategy for AI agent startups. The conversation explores how FDEs work closely with customers to bridge the gap between product capabilities and customer needs, driving product discovery and value in emerging markets like AI agents.
Dan Martell ranks the most profitable businesses to start before 2026, evaluating them based on speed to first dollar, ease of learning, long-term profitability, and potential for future sale. He discusses 15 different business models, placing them in tiers from S (no-brainer) to F (scammy), with real estate, AI automation agency, and coaching/online courses ranking among the top options.
In this episode of How I Invest, David Weisburd interviews Eric Olson, CEO of Consensus, an AI search engine for scientific research, discussing how startups can differentiate themselves in the rapidly evolving AI landscape by maintaining a laser-focus on solving specific user problems. Eric argues that vertical products can coexist with horizontal AI models by delivering exceptional, tailored experiences that big tech companies cannot easily replicate due to their limited focus and risk tolerance.
Ashlee Vance discusses his experiences interviewing tech luminaries like Elon Musk, Brian Johnson, and Palmer Luckey, sharing insights into their personalities, work ethic, and the challenges of covering complex technological frontiers like quantum computing and fusion. He reflects on his journalistic career, highlighting the persistent and focused nature of innovators, and teases upcoming projects for his podcast Core Memory.
In this episode of the a16z Podcast, Matt Perrault and Colin McHugh discuss the "Little Tech Agenda" for AI policy, advocating for a regulatory approach that focuses on harmful use rather than development, and ensures startups can compete in the AI landscape while maintaining national technological leadership.
Howie Liu, CEO of Airtable, discusses the company's transformation into an AI-native platform, emphasizing the need to radically refound the company and break existing ways of working to remain competitive in the rapidly evolving AI landscape. He shares insights on building a successful startup, the importance of maintaining execution intensity, and the philosophical meaning of grit as the texture of life's challenging experiences.
Sal Khan discusses Khan Academy's evolution from simple math videos to a global learning platform, focusing on how AI could transform education by providing personalized, adaptive learning experiences while emphasizing that human teachers remain irreplaceable. He explores the potential of AI tutoring tools like Conmigo, which aim to support and enhance learning rather than replace human educators.
The episode discusses the unprecedented concentration of the S&P 500, with the top 10 stocks now comprising 40% of the index's value, driven primarily by tech companies and AI investments. The hosts explore the potential risks of this market structure, including the possibility of a significant market downturn if AI investments fail to deliver expected returns.
ElevenLabs co-founder Mati Staniszewski discusses the company's rapid growth from a dubbing-focused startup to a leading AI voice technology platform, achieving $200 million in annual recurring revenue in just 15 months. He shares insights on building a global AI company from Europe, the importance of research and product innovation, and the challenges of scaling a technology startup.
Archer is pioneering the next generation of aviation with electric vertical takeoff and landing (eVTOL) aircraft, aiming to revolutionize urban transportation and defense mobility. The company is developing the Midnight aircraft, which offers enhanced safety through multiple redundant engines, and is positioning itself to become a major player in the emerging air taxi market, with plans to showcase its technology during the 2028 Los Angeles Olympics.
A deep dive into the semiconductor industry's transformation driven by AI, featuring VanEck's Angus Shillington and Nick Frasse discussing the massive capital expenditure in AI, the rise of fabless semiconductor companies, and the potential long-term impact of this technological revolution. The conversation explores the growth of companies like NVIDIA, the unique investment opportunities in VanEck's semiconductor ETFs SMH and SMHX, and why this AI-driven semiconductor boom differs from previous tech cycles.
In this episode, Oji and Ezinne Udezue discuss how AI is reshaping the product management role, emphasizing the importance of adaptability, hands-on learning, and maintaining a curious and ethical approach to product development in an increasingly AI-driven landscape.
Zvi Mowshowitz discusses the current state of AI, including slightly extended timelines, ongoing concerns about AI alignment, and the challenges of model development across various companies. He highlights the importance of creating AI systems that genuinely want to be aligned and virtuous, while warning about potential risks from reinforcement learning and the dangers of trying to suppress AI's chain of thought.
In this a16z Podcast episode, Alex, founder of Stainless, discusses the evolution of APIs as the "dendrites of the Internet" and how his experience at Stripe led him to create a platform for generating high-quality SDKs and developer tools. The conversation explores the emerging challenges of designing APIs for both human developers and AI agents, highlighting the importance of thoughtful interface design, type safety, and context management in the era of large language models.
Explores the ongoing browser wars, discussing Brave's privacy-focused approach, potential AI integration, and the possibility of Apple acquiring privacy-centric browser companies. The episode also delves into the Google antitrust case, Polymarket's regulatory developments, and various startup and tech industry trends.
In this episode of 20VC, Meta CMO Alex Schultz discusses the evolving landscape of marketing, AI's impact on technology, and the importance of having a clear North Star metric for companies. He shares insights on growth strategies, brand marketing, and the potential future of AI, emphasizing the need for companies to be adaptable and innovative.
Google had a remarkable week, potentially powering Apple's Siri with its Gemini AI and successfully fending off a major antitrust challenge. The company also made waves with its impressive Nano Banana image generation model, solidifying its position as a leader in generative AI.
OpenEvidence is revolutionizing clinical decision support for physicians by providing a semantic search platform that helps doctors quickly find precise, evidence-based medical information. The company has rapidly become the primary operating system for clinical knowledge, used by 40% of doctors in the United States and providing crucial support in navigating the exponentially growing complexity of medical research.
A technical journey through the evolution of generative media, focusing on FAL's strategic pivot to specialize in optimizing image and video model inference, scaling from a few developers to serving over 2 million developers with 350 unique models across image, video, and audio generation.
A podcast episode exploring how AI is transforming education from K-12 to college, featuring interviews with an innovative school founder, a Princeton professor, and student perspectives on using AI for learning, motivation, and personal growth.
Gary Vaynerchuk discusses the transformative potential of AI in marketing, comparing its societal impact to the early days of electricity and highlighting both the fears and opportunities it presents. He believes AI will become deeply integrated into various industries, with consumers eventually accepting both AI-generated and human-created content, while emphasizing the importance of understanding the technology's nuanced evolution.
Brendan Kane shares insights on how to go viral on social media by understanding storytelling formats and creating content that captures audience attention. He emphasizes that success comes from consistently telling compelling stories and leveraging proven content formats, rather than relying on quick tricks or viral moments.
Brendan Kane discusses the art and science of going viral on social media, emphasizing that success comes from understanding storytelling formats and creating compelling content rather than relying on hacks or tricks. He shares insights from his book "Guide to Going Viral," highlighting the importance of crafting narratives that connect with audiences and leveraging social media platforms to reach millions without traditional marketing budgets.
Chris Valenzuela, CEO of Runway, discusses the company's journey in AI video technology, highlighting their growth from a small startup to a leading AI research lab that helps create impressive AI videos and worlds. The episode explores Runway's innovative models, their approach to creative AI, and their vision of transforming storytelling through technology.
Alex Cohen details his journey from getting fired from multiple companies to founding Hello Patient, a conversational AI startup for healthcare practices that recently raised a $22.5 million Series A. Throughout the episode, he discusses his unconventional path, love for healthcare software, and how his viral Twitter presence has helped him build his company.
A discussion with Canva co-founder Cliff Obrecht about recent venture capital trends, including Anthropic's massive $13 billion raise, OpenAI's acquisition of Statsig, and the evolving landscape of AI investments and technology. The conversation explores valuation dynamics, company growth strategies, and the potential impact of AI on various industries.
Dr. Roman Yampolskiy, a computer science professor and AI safety expert, warns that artificial general intelligence (AGI) could arrive by 2027, potentially leading to 99% unemployment and posing an existential threat to humanity. He argues that we cannot control superintelligent AI and that its development could result in human extinction, while also discussing his belief that we are likely living in a simulation created by a more advanced intelligence.
Uber, Lucid, and Neuro are partnering to launch a robotaxi service by 2026, targeting the Uber Black and Uber XL market with the Lucid Gravity SUV. The companies aim to create a safer, more affordable autonomous vehicle solution that could potentially reduce transportation costs and save lives.
Peter Diamandis and his Moonshot mates discuss groundbreaking AI developments, from Elon Musk's Colossus data center to emerging technologies that are rapidly transforming industries and human potential. The episode explores the accelerating pace of AI innovation, its impact on various sectors, and the potential for sustainable abundance through technological advancement.
Ryan Hudson discusses Zero Click, a platform building native advertising for AI systems that aims to make ad-supported free tiers viable for AI application developers through contextual, paid inference-time advertising. The conversation explores the potential benefits and challenges of AI advertising, including how to maintain user trust, create value for developers, and avoid the pitfalls of previous advertising revolutions.
Two pioneering neurotechnology experts discuss brain computer interfaces (BCIs) that can decode brain signals non-invasively, with potential applications ranging from helping paralyzed patients communicate to understanding consciousness states like comas. The podcast explores how these advanced BCIs could revolutionize interactions between human brains and digital technologies, offering glimpses into future medical treatments and potentially merging human cognition with artificial intelligence.
Jack Altman sits down with Martin Casado, a general partner at Andreessen Horowitz, to discuss the shifting dynamics of venture capital, the rise of AI infrastructure, and the importance of media and talent in the tech ecosystem. They delve into the evolution of venture capital, exploring specialization, investment strategies, and the transformative potential of AI across various industries.
A conversation about Mirage, a real-time video-to-video AI model that can transform live video streams into different styles and settings, exploring its potential to revolutionize gaming, creativity, and human-AI interaction.
Michael Truell shares the journey of founding Cursor, an AI-powered code editor, starting from early experiments with robotics and AI in high school to pivoting through multiple startup ideas before finding success. Through persistent iteration and a vision of transforming software development, Truell and his cofounders grew Cursor from zero to 100 million in just one year, challenging existing tools like GitHub Copilot.
Brett Caughran and David Plon discuss the rapid evolution of AI tools in investment research, highlighting their potential to enhance productivity and generate insights while emphasizing the continued importance of human expertise and thoughtful implementation. They explore how AI can help analysts work more efficiently, generate ideas, and monitor investment theses, but caution against over-reliance and stress the need for careful, contextualized use of these emerging technologies.
Martin Casado discusses his journey at Andreessen Horowitz, the evolution of venture capital, and the importance of specialization in a rapidly growing tech market. He shares insights on AI, infrastructure, open source, and the changing role of venture capitalists in supporting founders and navigating competitive landscapes.
Jason and Alex discuss Tesla's Optimus robot, predicting it will revolutionize the world more than the internet, and also cover Anthropic's massive $13 billion funding round and the potential future of AI and smartphones.
Here's a concise two-sentence description of the episode: Benedict Evans, a technology analyst known for his insightful perspectives, discusses the current state of AI, exploring its potential as a platform shift and drawing parallels with past technological transformations. He offers nuanced views on AI's impact, challenging both overhyped and overly pessimistic narratives while examining how different tech companies are positioning themselves in this emerging landscape.
Here's a two-sentence description for the episode: Pinterest CEO Bill Ready discusses his mission to transform social media by prioritizing user well-being over engagement, advocating for a more positive and intentional online experience. Through innovative approaches like tuning AI for positivity, protecting younger users, and focusing on "time well spent" instead of maximizing screen time, Ready aims to challenge the current social media business model and create a healthier digital environment.
Here's a two-sentence description for the episode: In this episode, Henry discusses his innovative "seed strapping" approach to startup funding, leveraging AI to help founders build lean, efficient companies without traditional venture capital constraints. He demonstrates this through his own AI-powered VC tool and a Lean AI Leaderboard, highlighting how AI is enabling entrepreneurs to create successful businesses with smaller teams and more flexible funding models.
Here's a two-sentence description for the episode: Nick Frosst, co-founder of Cohere, discusses the evolution of AI, critiquing Sam Altman's AGI predictions and emphasizing the importance of enterprise-focused language models. He shares insights on the potential of AI to transform work, the challenges of technological hype, and Cohere's mission to build a generational company focused on solving real-world problems.
Here's a concise two-sentence description for the episode: Justin Freishtat, a former door-to-door salesman turned investor, discusses Safe Space Global, an AI technology company focused on creating safer environments in schools, prisons, and other public spaces. The interview explores the company's mission to prevent school shootings, its innovative ambient AI technology, and Justin's entrepreneurial journey from sales to strategic investing.
Here's a 2-sentence description for the episode: In this insightful conversation, Veronica Shelton, co-founder of Oak Theory, discusses the intersection of neurodiversity, technology, and accessibility, sharing her unique perspective as a woman of color in the tech industry. She explores the transformative potential of AI, the importance of adaptability in the workplace, and the launch of her new media project "Under the Oak," which aims to critically examine technology's psychological and social impacts.
Here's a two-sentence description for the episode: Nvidia reported a record-breaking $46.7 billion quarterly revenue, with complex geopolitical challenges surrounding its China chip sales. The episode also explores the U.S. imposing a 50% tariff on India and analyzes California's efforts to revive Hollywood through tax incentives, ultimately concluding that the entertainment industry's structural decline cannot be reversed by tax breaks.
Here's a two-sentence description for the episode: In this episode of Prof G Markets, Donald Trump attempts to fire Federal Reserve Governor Lisa Cook over unproven allegations of mortgage fraud, raising concerns about the independence of the Federal Reserve. The podcast also discusses Eli Lilly's promising new oral obesity drug and explores strategies for young professionals to remain employable in the age of artificial intelligence.
Here's a two-sentence description for the episode: In this episode of Right About Now, Matt Britton, author of "Generation AI," discusses the transformative impact of artificial intelligence on business, culture, and society, particularly focusing on how Generation Alpha will be the first generation to grow up entirely immersed in AI technology. Britton explores the future of work, education, and technology, emphasizing the importance of speed, adaptability, and understanding AI's potential to revolutionize various aspects of human life.
Here's a 2-sentence description for the episode: In this episode of Prof G Markets, Josh Brown discusses the recent tech sell-off driven by Sam Altman's comments about AI excitement, a Meta restructuring rumor, and an MIT study suggesting low returns on generative AI investments. The conversation also explores the implications of Trump's executive order allowing alternative assets in 401(k)s, with Brown arguing that while the move isn't inherently dangerous, venture capital investments in retirement accounts are ill-advised.
<p>>> Get The Book (Buy Back Your Time): https://bit.ly/3pCTG78 </p><p>>> Subscribe to My Newsletter: https://bit.ly/3</p><p>If you’re worried you might be building a career for a job that won’t exist in 10 years, you should be. I’ve analyzed thousands of AI companies and market trends, and in this episode, I reveal the 6 highest-paying jobs that will survive the next few decades… plus the ones that are disappearing fast.</p>